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Note 11 - Related-party Transactions (Details Textual) - USD ($) $ in Thousands						1 Months Ended		9 Months Ended	12 Months Ended
	Aug. 31, 2024	Aug. 30, 2024	Jun. 15, 2021	Feb. 18, 2019	Aug. 11, 2017	Aug. 31, 2024	Oct. 31, 2023	Sep. 30, 2023	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022	Oct. 31, 2024	Mar. 14, 2023
Research and Development Expense, Total									$ 3,255	$ 3,322	$ 3,996
Messa Holdings LLC [Member]
Equity Method Investment, Ownership Percentage									50.00%
FDA-Approved ANDA For Nitisinone [Member]
Payments to Acquire Marketing Rights							$ 150
Commitment, Allocation of Profits, Percentage							80.00%
Obligation Based on Acceptance of FDA of NDA for product [Member] \| FDA-Approved ANDA For Nitisinone [Member]
Payments to Acquire Marketing Rights							$ 500
Tulex Pharmaceuticals, Inc. (“Tulex”) [Member] \| Obligation Based on First Commercial Sale of Product [Member]
Other Commitment													$ 250
Tulex Pharmaceuticals, Inc. (“Tulex”) [Member] \| Obligation Based on Acceptance of FDA of NDA for product [Member]
Other Commitment													$ 200
Selenix [Member] \| DS-200 [Member]
Commitment, Allocation of Profits, Percentage	45.00%	50.00%				45.00%
U.S. and Canadian rights to Crossject S.A.’s [Member] \| Crossject [Member]
Research and Development Expense, Total			$ 500
Royalty on Net Sales of Products, Percent			10.00%
Related Party, Eyemax LLC [Member] \| The Eyemax Agreement [Member]
Related Party Transaction, Terms (Year)					10 years
Related Party Transaction, Terms, Renewal (Year)					2 years
Related Party, Eyemax LLC [Member] \| The Eyemax Agreement [Member] \| Research and Development Expense [Member]
Related Party Transaction, Amounts of Transaction					$ 250
Related Party, Eyemax LLC [Member] \| The Amended Agreement [Member]
Related Party Transaction, Amounts of Transaction									$ 0	$ 0
Revenues								$ 1,840
Related Party, Bausch Health [Member] \| Royalty [Member]
Related Party Transaction, Rate				12.00%
Chief Executive Officer [Member] \| Sean E. Brynjelsen [Member]
Subsidiary, Ownership Percentage, Parent									100.00%
Related Party [Member]
Other Liabilities, Current												$ 220