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Note 2 - Summary of Significant Accounting Policies - Schedule of Intangible Assets (Details) - USD ($)
$ in Thousands
Mar. 31, 2026
Feb. 28, 2026
Dec. 31, 2025
Finite lived intangible, gross $ 51,231   $ 37,262
Intangible asset, accumulated amortization 7,493   6,384
Intangible assets, net $ 43,738   $ 30,878
Carglumic Acid Product Rights [Member]      
Useful life (Year) 10 years   10 years
Finite lived intangible, gross $ 3,250   $ 3,250
Intangible asset, accumulated amortization 1,435   1,354
Intangible assets, net $ 1,815   $ 1,896
Betaine Anhydrous Product Rights [Member]      
Useful life (Year) 5 years   5 years
Finite lived intangible, gross $ 2,125   $ 2,125
Intangible asset, accumulated amortization 1,505   1,399
Intangible assets, net $ 620   $ 726
Nitisinone Product Rights [Member]      
Useful life (Year) 5 years   5 years
Finite lived intangible, gross $ 650   $ 650
Intangible asset, accumulated amortization 325   292
Intangible assets, net $ 325   $ 358
PKU GoLike [Member]      
Useful life (Year) 10 years   10 years
Finite lived intangible, gross $ 1,868   $ 1,868
Intangible asset, accumulated amortization 374   327
Intangible assets, net $ 1,494   $ 1,541
Increlex [Member]      
Useful life (Year) 10 years   10 years
Finite lived intangible, gross $ 21,250   $ 21,250
Intangible asset, accumulated amortization 2,732   2,200
Intangible assets, net $ 18,518   $ 19,050
Glazin [Member]      
Useful life (Year) 10 years   10 years
Finite lived intangible, gross $ 8,119   $ 8,119
Intangible asset, accumulated amortization 1,015   812
Intangible assets, net 7,104   $ 7,307
In Process Research and Development [Member]      
Finite lived intangible, gross 1,000    
Intangible asset, accumulated amortization 0    
Intangible assets, net $ 1,000    
Hemangeol [Member]      
Useful life (Year) 10 years 10 years  
Finite lived intangible, gross $ 12,969    
Intangible asset, accumulated amortization 107    
Intangible assets, net $ 12,862 $ 12,969