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Consolidated Statements of Cash Flows - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020
Cash flows from operating activities: |  |
Net loss | $ (122,764,000) | $ (101,660,000)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 829,000 | 540,000
Stock-based compensation expense | 8,331,000 | 797,000
In-process research and development expenses | 10,848,000 | 71,745,000
Issuance of common stock to Erasca Foundation | 17,497,000 |
Amortization (accretion) on investments, net | 108,000 | (38,000)
Change in fair value of preferred stock purchase right liability | (1,615,000) | (7,358,000)
Gain on remeasurement of operating lease assets and liabilities | (539,000) |
Changes in operating assets and liabilities: |  |
Prepaid expenses and other current and long-term assets | (6,711,000) | (930,000)
Accounts payable | 1,344,000 | (380,000)
Accrued expenses and other current liabilities | 11,859,000 | 4,693,000
Operating lease assets and liabilities, net | 1,213,000 | (95,000)
Net cash used in operating activities | (79,600,000) | (32,686,000)
Cash flows from investing activities: |  |
Purchases of investments | (105,815,000) | (99,202,000)
Maturities of investments | 60,110,000 | 66,692,000
In-process research and development | (7,680,000) | (37,745,000)
Purchases of property and equipment | (11,205,000) | (947,000)
Net cash used in investing activities | (64,590,000) | (71,202,000)
Cash flows from financing activities: |  |
Proceeds from the issuance of common stock in initial public offering, net of discounts and issuance costs | 316,999,000 |
Proceeds from the issuance of convertible preferred stock, net of issuance costs | 119,393,000 | 136,975,000
Proceeds from the exercise of stock options, net of repurchases | 1,385,000 | 3,018,000
Proceeds from the disgorgement of stockholder's short-swing profits | 553,000 |
Proceeds from issuance of common stock under the Employee Stock Purchase Plan | 1,067,000 |
Net cash provided by financing activities | 439,397,000 | 139,993,000
Net increase in cash, cash equivalents and restricted cash | 295,207,000 | 36,105,000
Cash, cash equivalents and restricted cash at beginning of the period | 65,688,000 | 29,583,000
Cash, cash equivalents and restricted cash at end of the period | 360,895,000 | 65,688,000
Supplemental disclosure of noncash investing and financing activity: |  |
Issuance of common stock to Erasca Foundation | 17,497,000 |
Issuance of common stock in connection with asset acquisition | 1,680,000 |
Issuance of common stock in connection with license agreement | 5,488,000 |
Issuance of Series B-2 convertible preferred stock in connection with asset acquisition |  | 30,000,000
Amounts accrued for purchases of property and equipment | 3,807,000 | 74,000
Amounts accrued for in-process research and development expenses |  | 4,000,000
Conversion of preferred stock to common stock upon initial public offering | 340,798,000 |
Vesting of early exercised options | 692,000 | 322,000
Preferred stock purchase right liability |  | 8,973,000
Supplemental disclosure of noncash operating activities: |  |
Operating lease assets obtained in exchange for lease obligation | 17,498,000 | $ 28,000
Tenant improvement allowance included in operating lease liabilities | 16,774,000 |
Reduction in operating lease assets due to lease amendment | $ 1,271,000 |

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