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Stock-based Compensation - Assumptions used to Determine Fair Value of Stock Option Grants and Stock to be Purchased under ESPP (Details)
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
ESPP    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Risk-free interest rate   0.00%
Risk-free interest rate, minimum 0.05%  
Risk-free interest rate, maximum 0.64%  
Expected volatility   0.00%
Expected volatility, minimum 70.99%  
Expected volatility, maximum 91.69%  
Expected dividend yield 0.00% 0.00%
ESPP | Minimum    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Expected term (in years) 4 months 20 days  
ESPP | Maximum    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Expected term (in years) 2 years  
Stock Options    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Risk-free interest rate, minimum 0.59% 0.37%
Risk-free interest rate, maximum 1.34% 1.22%
Expected volatility, minimum 81.93% 74.72%
Expected volatility, maximum 85.35% 77.81%
Expected term (in years) 6 years 29 days  
Expected dividend yield 0.00% 0.00%
Stock Options | Minimum    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Expected term (in years)   6 years 7 days
Stock Options | Maximum    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Expected term (in years)   6 years 3 months