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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
 3 Months Ended 12 Months Ended
Mar. 31, 2023
Mar. 31, 2022
Dec. 31, 2022
Cash flows from operating activities:      
Net loss $ (33,199,000) $ (36,458,000)  
Adjustments to reconcile net loss to net cash used in operating activities:      
Depreciation and amortization 894,000 403,000  
Stock-based compensation expense 6,845,000 4,442,000  
In-process research and development expenses   2,000,000  
(Accretion) amortization on marketable securities, net (975,000) 17,000  
Changes in operating assets and liabilities:      
Prepaid expenses and other current and long-term assets 670,000 (5,515,000)  
Accounts payable 446,000 1,898,000  
Accrued expenses and other current and long-term liabilities (4,363,000) (3,656,000)  
Operating lease assets and liabilities, net 3,324,000 11,063,000  
Net cash used in operating activities (26,358,000) (25,806,000)  
Cash flows from investing activities:      
Purchases of marketable securities (24,280,000) (9,758,000)  
Maturities of marketable securities 60,200,000 19,300,000  
In-process research and development (20,000,000) (2,000,000)  
Payment made for investment in equity securities   (2,000,000)  
Purchases of property and equipment (1,206,000) (7,336,000)  
Net cash provided by (used in) investing activities 14,714,000 (1,794,000)  
Cash flows from financing activities:      
Proceeds from the exercise of stock options 183,000 460,000  
Net cash provided by financing activities 183,000 460,000  
Net decrease in cash, cash equivalents and restricted cash (11,461,000) (27,140,000)  
Cash, cash equivalents and restricted cash at beginning of the period 284,625,000 360,895,000 $ 360,895,000
Cash, cash equivalents and restricted cash at end of the period 273,164,000 333,755,000 $ 284,625,000
Supplemental disclosure of noncash investing and financing activities:      
Amounts accrued for purchases of property and equipment 38,000 1,324,000  
Vesting of early exercised options $ 243,000 $ 479,000