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Basis of Presentation Summary of Significant Accounting Policies and Nature of Operations (Details Narrative) - USD ($)
 12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Net loss $ (14,417,266) $ (10,676,747)  
Recognized grant income 100,000    
Cash and cash equivalents 21,531,665 17,958,989 $ 24,637,295
Accumulated deficit (129,155,608) (114,738,342)  
Net Cash Used In Operating Activities (8,570,421) (6,667,697)  
Working capital 17,100,000    
US Treasury Bills 13,000,000 9,000,000  
Loss on this equity method investment 0 3,300,000  
Cash, FDIC insured amount 250,000    
Patents 0 1,000,000  
Amortization expense 100,000 100,000  
Carrying value of trademarks 100,000 100,000  
Impairment loss on patents $ 1,100,000 0  
Enfissions LLC [Member]      
Net loss   $ 5,500,000  
Equity method investment, ownership interest 50.00% 50.00%  
One Notable Financial Institution [Member]      
Deposit $ 8,500,000 $ 9,000,000