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Investments - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands |  | 3 Months Ended | 12 Months Ended
--- | --- | --- | ---
Mar. 04, 2015 | Sep. 30, 2018 | Mar. 31, 2018 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Investments Equity Securities [Abstract] |  |  |  |  |  |
Purchase of common stock, value |  |  |  | $ 500 | $ 0 | $ 0
Investment impairment charges |  |  |  | $ (4,678) |  |
Bone Biologics Inc [Member] |  |  |  |  |  |
Investments Equity Securities [Abstract] |  |  |  |  |  |
Warrants held for share purchases |  |  |  | 13,000 |  |
Weighted average exercise price of warrant |  |  |  | $ 14.32 |  |
Warrants exercisable period |  |  |  | 7 years |  |
Warrant expiration year |  |  |  | 2020 |  |
Purchase of common stock, value |  |  | $ 500 |  |  |
Bone Biologics Inc [Member] | Common Stock [Member] |  |  |  |  |  |
Investments Equity Securities [Abstract] |  |  |  |  |  |
Purchase of stock, shares |  |  | 25,000 |  |  |
Bone Biologics Inc [Member] | ASU 2016-01 [Member] | CommonStock and Warrants [Member] |  |  |  |  |  |
Investments Equity Securities [Abstract] |  |  |  |  |  |
Investment impairment charges |  | $ 4,400 |  |  |  |
eNeura Note [Member] | eNeura Inc [Member] |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |
Non-refundable fees paid | $ 300 |  |  |  |  |
Accrued interest rate on promissory note | 8.00% |  |  |  |  |
Maturity description of Promissory note |  |  |  | The eNeura Note will mature on March 4, 2019 |  |
Debt Instrument, Maturity Date |  |  |  | Mar. 04, 2019 |  |
eNeura Note [Member] | eNeura Inc [Member] | Convertible Debt Securities [Member] |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |
Principal amount of promissory note | $ 15,000 |  |  |  |  |
eNeura Note [Member] | eNeura Inc [Member] | Preferred Stock [Member] |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |
Conversion price per share |  |  |  | $ 7.30 |  |
eNeura Note [Member] | eNeura Inc [Member] | Minimum [Member] |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |
Third party acquisition |  |  |  | 50.00% |  |

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