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Fair Value Measurements and Investments - Additional Information (Detail) $ / shares in Units, SFr in Millions |  |  |  | 1 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | --- | ---
Oct. 01, 2020 USD ($) | Mar. 01, 2019 $ / shares | Apr. 30, 2018 USD ($) | Oct. 01, 2019 USD ($) | Dec. 31, 2020 USD ($) | Dec. 31, 2018 USD ($) | Oct. 01, 2020 CHF (SFr)
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |  |  |  |  |  |  |
Carrying value of investment |  |  |  |  | $ 5,000.0 |  |
Spinal Kinetics [Member] |  |  |  |  |  |  |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |  |  |  |  |  |  |
Milestone achievement period |  |  | 5 years |  | 12 months |  |
Contingent consideration |  |  |  |  | $ 35,400 |  |
Spinal Kinetics [Member] | Other Current Liabilities |  |  |  |  |  |  |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |  |  |  |  |  |  |
Contingent consideration |  |  |  |  | 14,900 |  |
Spinal Kinetics [Member] | Other Noncurrent Liabilities |  |  |  |  |  |  |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |  |  |  |  |  |  |
Contingent consideration |  |  |  |  | $ 20,500 |  |
Maximum [Member] | Spinal Kinetics [Member] |  |  |  |  |  |  |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |  |  |  |  |  |  |
Future milestone payments |  |  | $ 60,000,000.0 |  |  |  |
US Food And Drug Administration [Member] | Spinal Kinetics [Member] |  |  |  |  |  |  |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |  |  |  |  |  |  |
Future milestone payments |  |  | 15,000,000.0 |  |  |  |
Revenue Milestone [Member] | Spinal Kinetics [Member] |  |  |  |  |  |  |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |  |  |  |  |  |  |
Future milestone payments |  |  | $ 45,000,000.0 |  |  |  |
eNeura Inc [Member] |  |  |  |  |  |  |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |  |  |  |  |  |  |
Payments of restructured debt security |  |  |  | $ 4,000,000.0 |  |  |
Adjusted carrying value of restructured debt |  |  |  | 4,000,000.0 |  |  |
Other-than-temporary impairment on restructured debt securities |  |  |  | 6,500,000 |  |  |
eNeura Inc [Member] | Reclassification Out of Accumulated Other Comprehensive Income (Loss) [Member] |  |  |  |  |  |  |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |  |  |  |  |  |  |
Unrealized gains on restructured debt securities |  |  |  | $ 5,200,000 |  |  |
eNeura Inc [Member] | Amended and Restated Senior Secured Promissory Note [Member] |  |  |  |  |  |  |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |  |  |  |  |  |  |
Maturity date |  |  |  |  | Mar. 04, 2019 |  |
Principal amount of the debt security |  |  |  |  | $ 15,000.0 |  |
Accrued interest rate |  |  |  |  | 8.00% |  |
Debt securities, maturity date description |  |  |  |  | Amended and Restated Senior Secured Promissory Note with eNeura (the “Restructured Debt Security”) to restructure the debt security, which extended the maturity date to the earlier of (i) March 4, 2022, (ii) the effective date of a change in control, or (iii) the effective date of an initial public offering by eNeura, and which also eliminated the conversion feature included within the original note. |  |
Warrant exercisable price per share | $ / shares |  | $ 0.01 |  |  |  |  |
Warrant contractual term |  | 10 years |  |  |  |  |
Debt securities amortized cost basis |  |  |  |  |  | $ 9,000,000.0 |
Equity Warrants | Bone Biologics Inc [Member] |  |  |  |  |  |  |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |  |  |  |  |  |  |
Impairment charges on investment |  |  |  |  | $ 200,000 | $ 4,400,000 |
Neo Medical SA [Member] |  |  |  |  |  |  |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |  |  |  |  |  |  |
Convertible loans | SFr |  |  |  |  |  |  | SFr 4.6
Convertible loans interest rate |  |  |  |  |  |  | 8.00%
Maturity date | Oct. 01, 2024 |  |  |  |  |  |
Convertible loan credit losses |  |  |  |  | 0 |  |
Debt securities amortized cost basis |  |  |  |  | $ 5,279,000 |  |
Preferred Stock [Member] | Neo Medical SA [Member] |  |  |  |  |  |  |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |  |  |  |  |  |  |
Amount of Preferred stock consideration | $ 5,000,000.0 |  |  |  |  |  |

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