EX-21.1 4 ofix-ex21_1.htm EX-21.1

Exhibit 21.1

The following is a list of our significant subsidiaries:

Company |  | Country of Incorporation |  | Ultimate Ownership by Parent
Orthofix Australia Pty. Ltd. |  | Australia |  | 100%
Orthofix do Brasil Ltda. |  | Brazil |  | 100%
Orthofix S.A. |  | France |  | 100%
Orthofix GmbH |  | Germany |  | 100%
Orthofix Spine GmbH |  | Germany |  | 100%
Orthofix S.r.l. |  | Italy |  | 100%
Orthofix Netherlands B.V. |  | Netherlands |  | 100%
Implantes y Sistemas Medicos, Inc. |  | Puerto Rico |  | 100%
Orthofix AG |  | Switzerland |  | 100%
Orthofix Limited |  | UK |  | 100%
Orthofix US LLC |  | US |  | 100%
Spinal Kinetics, LLC |  | US |  | 100%
SeaSpine Holdings Corporation |  | US |  | 100%
IsoTis International SARL |  | Switzerland |  | 100%
IsoTis OrthoBiologics, Inc. |  | US |  | 100%
IosTis, Inc. |  | US |  | 100%
SeaSpine, Inc. |  | US |  | 100%
SeaSpine Sales LLC |  | US |  | 100%
SeaSpine Orthopedics Corporation |  | US |  | 100%
Theken Spine, LLC |  | US |  | 100%
SeaSpine Orthopedics IntermediateCo, Inc. |  | US |  | 100%
Project Maple Leaf Holdings ULC |  | British Columbia |  | 100%
7D Surgical ULC |  | British Columbia |  | 100%
7D Surgical USA Inc. |  | US |  | 100%
7D Surgical International Inc. |  | Barbados |  | 100%