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Share-based Compensation - Share Options (Details) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended
Mar. 31, 2023
Dec. 31, 2022
Mar. 31, 2023
Mar. 31, 2022
Number of Shares        
Granted (in shares)     2,076,950  
Exercised (in shares)     (3,790)  
Forfeited (in shares)     (131,350)  
Outstanding, ending balance (in shares) 7,034,542   7,034,542  
Exercisable (in shares) 2,600,262   2,600,262  
Unvested (in shares) 4,434,280   4,434,280  
Weighted Average Exercise Price        
Outstanding, beginning balance (in dollars per share)     $ 13.55  
Granted (in dollars per share)     10.08  
Exercised (in dollars per share)     0.01  
Forfeited (in dollars per share)     24.13  
Outstanding, ending balance (in dollars per share) $ 13.25 $ 13.55 13.25  
Exercisable (in dollars per share) 10.86   10.86  
Unvested (in dollars per share) $ 14.65   $ 14.65  
Weighted Average Remaining Contractual Term (Years) and Aggregate Intrinsic Value        
Outstanding balance (in years) 8 years 7 months 17 days 8 years 4 months 17 days    
Exercisable (in years) 7 years 6 months 10 days      
Unvested (in years) 9 years 3 months 7 days      
Outstanding, aggregate intrinsic value $ 17,648 $ 13,013 $ 17,648  
Exercisable, aggregate intrinsic value 15,048   15,048  
Unvested, aggregate intrinsic value 2,600   2,600  
Aggregate intrinsic value of options exercised during the period (less than in 2023)     $ 100 $ 4,900
Granted (in dollars per share)     $ 8.27 $ 11.38
Unrecognized compensation cost of options $ 42,300   $ 42,300 $ 35,200
Ordinary shares        
Number of Shares        
Exercised (in shares)     (3,790) (376,158)
Share-Based Payment Arrangement, Option [Member]        
Weighted Average Remaining Contractual Term (Years) and Aggregate Intrinsic Value        
Period for recognition (in years)     3 years 1 month 6 days 3 years 4 months 24 days
Share-Based Payment Arrangement, Option [Member] | Ordinary shares        
Number of Shares        
Outstanding, beginning balance (in shares)     5,092,732  
Outstanding, ending balance (in shares)   5,092,732