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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Cash flows from operating activities: |  |  |
Net loss | $ (108,296) | $ (113,315) | $ (65,226)
Adjustments to reconcile net loss to net cash used in operating activities |  |  |
Stock-based compensation expense | 14,051 | 19,433 | 14,378
Depreciation and amortization | 11,296 | 8,432 | 6,014
Noncash operating lease cost | 1,859 | 4,446 | 2,950
Amortization of premium (discount) on short-term investments | (2,000) | 57 | 2,031
Noncash restructuring and other charges | 3,605 |  |
Noncash lease impairment expense | 5,565 |  |
Other | 153 | 103 | 169
Changes in operating assets and liabilities |  |  |
Accounts receivable | (1,088) | 1,825 | (12,118)
Inventory and other deferred costs | (1,934) | (2,982) | 29
Prepaid expenses and other assets | 3,748 | 484 | (2,658)
Accounts payable | 5,178 | 3,089 | (1,457)
Accrued and other current liabilities | 742 | (1,479) | 3,365
Contract liabilities | 5,952 | (2,718) | (17,052)
Operating lease liabilities | 894 | 12,811 | (962)
Other long-term liabilities | (10) | (419) | (291)
Net cash used in operating activities | (56,258) | (70,233) | (70,828)
Cash flows from investing activities: |  |  |
Purchases of available-for-sale debt securities | (103,945) | (121,490) | (267,128)
Proceeds from maturities of available-for-sale debt securities | 127,955 | 223,923 | 213,083
Proceeds from sales of available-for-sale debt securities |  |  | 5,059
Purchases of property and equipment | (10,911) | (49,896) | (11,083)
Net cash provided by (used in) investing activities | 13,099 | 52,537 | (60,069)
Cash flows from financing activities: |  |  |
Proceeds from public offerings, net of underwriting discounts and commissions |  |  | 162,258
Payments of costs related to public offerings |  |  | (342)
Proceeds from sales of common stock under ATM facility, net of commissions | 3,513 |  |
Proceeds from loans | 3,438 | 1,194 | 5,167
Repayments of loans | (3,264) | (2,293) | (1,857)
Proceeds from exercise of equity awards | 1,344 | 2,465 | 4,474
Net cash provided by financing activities | 11,031 | 1,366 | 169,700
Effect of exchange rates on cash, cash equivalents and restricted cash | (16) | (127) | 47
Net change in cash, cash equivalents and restricted cash | (32,144) | (16,457) | 38,850
Cash, cash equivalents and restricted cash, beginning of period | 90,918 | 107,375 | 68,525
Cash, cash equivalents and restricted cash, end of period | 58,774 | 90,918 | 107,375
Reconciliation of cash, cash equivalents and restricted cash to the consolidated balance sheets: |  |  |
Cash and cash equivalents | 56,984 | 89,128 | 105,585
Restricted cash, included in other long-term assets | 1,790 | 1,790 | 1,790
Total cash, cash equivalents and restricted cash | 58,774 | 90,918 | 107,375
Supplemental cash flow information: |  |  |
Cash paid for income taxes, net of refunds | 64 | 47 | 39
Acquisition of property and equipment included in accounts payable and accrued liabilities | 104 | $ 3,917 | $ 3,006
Tempus Warrants |  |  |
Adjustments to reconcile net loss to net cash used in operating activities |  |  |
Noncash charges related to liability | 4,027 |  |
Cash flows from financing activities: |  |  |
Proceeds from issuance of Warrants | $ 6,000 |  |

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