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Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017
Revenue:
License revenue	$ 478
Type of Revenue [Extensible List]	us-gaap:LicenseMember
Operating expenses:
Research and development	$ 9,939	$ 14,387
General and administrative	17,214	8,466
Total operating expenses	27,153	22,853
Operating loss	(26,675)	(22,853)
Other income (expense):
Other income	63
Change in fair value of derivative financial instruments	(3,577)	(3,443)
Foreign exchange gain (loss)	1,566	(1,728)
Total other expense	(1,948)	(5,171)
Net loss	(28,623)	(28,024)
Other comprehensive (loss) income:
Foreign currency translation adjustments	(638)	1,775
Comprehensive loss	$ (29,261)	$ (26,249)
Net loss per share
Basic and diluted	$ (1.26)	$ (1.50)
Weighted average shares outstanding
Basic and diluted	22,786,192	18,632,740

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