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Sole-Source Cost-Sharing Agreement and Cooperative Research and Development Agreement - Additional Information (Details) - USAMRMC - USD ($)
 1 Months Ended 3 Months Ended 12 Months Ended
Jul. 31, 2015
Sep. 30, 2017
Dec. 31, 2018
Schedule Of Cost Sharing Agreement And Cooperative Research And Development Agreement [Line Items]      
Expiration date of original contract     Dec. 31, 2016
Reimbursement received     $ 3,000,000
Cooperative Research and Development Agreement      
Schedule Of Cost Sharing Agreement And Cooperative Research And Development Agreement [Line Items]      
Expiration year of original contract   2018  
Extended expiration date of original contract   Dec. 31, 2021  
Maximum      
Schedule Of Cost Sharing Agreement And Cooperative Research And Development Agreement [Line Items]      
Reimbursed trial cost $ 3,000,000