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Common Stock and Warrants - Summary of Warrant Activity (Details)
12 Months Ended
Dec. 31, 2020
$ / shares
shares
Dec. 31, 2020
$ / shares
shares
Dec. 31, 2020
$ / shares
shares
Dec. 31, 2020
$ / shares
shares
Dec. 31, 2019
$ / shares
shares
Dec. 31, 2019
$ / shares
shares
Class Of Warrant Or Right [Line Items]            
Number of Warrants, Exercised (2,025) (2,025)        
Number of Warrants, Outstanding 341,905 341,905 341,905 341,905    
CAD            
Class Of Warrant Or Right [Line Items]            
Number of Warrants, Outstanding     68,351 68,351 95,799 95,799
Number of Warrants, Cancelled/Expired         (26,352) (26,352)
Number of Warrants, Exercised         (1,096) (1,096)
Number of Warrants, Outstanding         68,351 68,351
Number of Warrants, Outstanding and exercisable 68,351 68,351 68,351 68,351    
Weighted-Average Exercise Price, Outstanding | $ / shares       $ 428.75   $ 381.15
Weighted Average Exercise Price, Cancelled/Expired | $ / shares           262.50
Weighted-Average Exercise Price, Exercised | $ / shares           262.50
Weighted-Average Exercise Price, Outstanding | $ / shares           $ 428.75
Weighted-Average Exercise Price, Outstanding and exercisable | $ / shares   $ 428.75   $ 428.75    
USD            
Class Of Warrant Or Right [Line Items]            
Number of Warrants, Outstanding     18,607 18,607 18,607 18,607
Number of Warrants, Granted     273,554 273,554    
Number of Warrants, Cancelled/Expired     (18,607) (18,607)    
Number of Warrants, Outstanding         18,607 18,607
Number of Warrants, Outstanding and exercisable 273,554 273,554 273,554 273,554    
Weighted-Average Exercise Price, Outstanding | $ / shares     $ 428.32   $ 428.32  
Weighted-Average Exercise Price, Granted | $ / shares     16.04      
Weighted Average Exercise Price, Cancelled/Expired | $ / shares     428.32      
Weighted-Average Exercise Price, Outstanding | $ / shares         $ 428.32  
Weighted-Average Exercise Price, Outstanding and exercisable | $ / shares $ 16.04   $ 16.04