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Share Based Payments - Summary of Stock Option Activity (Details) - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]
Number of Stock Options, Beginning balance outstanding	99,018	94,475
Number of Stock Options, Granted	42,988	33,337
Number of Stock Options, Forfeited		(13,939)
Number of Stock Options Forfeited/Cancelled	(28,448)
Number of Stock Options, Exercised		(14,855)
Number of Stock Options, Ending balance outstanding	113,558	99,018	94,475
Number of Stock Options, Exercisable	57,725
Weighted Average Remaining Contractual Life	7 years 9 months	7 years 9 months 10 days	5 years 1 month 28 days
Weighted Average Remaining Contractual Life, Exercisable	6 years 6 months 21 days
Weighted Average Exercise Price, Beginning balance outstanding	$ 236.63	$ 249.87
Weighted Average Exercise Price, Granted	15.20	162.74
Weighted Average Exercise Price, Forfeited		298.55
Weighted Average Exercise Price, Forfeited/Cancelled	210.57
Weighted Average Exercise Price, Exercised		96.95
Weighted Average Exercise Price, Ending balance outstanding	159.33	$ 236.63	$ 249.87
Weighted Average Exercise Price, Exercisable	$ 117.90
Aggregate Intrinsic Value, Beginning balance outstanding		$ 8,308
Aggregate Intrinsic Value, Ending balance outstanding			$ 8,308

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The number of shares into which fully or partially vested stock options outstanding as of the balance sheet date can be currently converted under the option plan.

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The weighted-average price as of the balance sheet date at which grantees can acquire the shares reserved for issuance on vested portions of options outstanding and currently exercisable under the stock option plan.

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For presentations that combine terminations, the number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan or that expired.

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Weighted average price of options that were either forfeited or expired.

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Gross number of share options (or share units) granted during the period.

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Amount by which the current fair value of the underlying stock exceeds the exercise price of options outstanding.

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Number of options outstanding, including both vested and non-vested options.

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Weighted average price at which grantees can acquire the shares reserved for issuance under the stock option plan.

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Weighted average price at which option holders acquired shares when converting their stock options into shares.

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Weighted average per share amount at which grantees can acquire shares of common stock by exercise of options.

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Weighted average remaining contractual term for vested portions of options outstanding and currently exercisable or convertible, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Weighted average remaining contractual term for option awards outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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