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License and Collaboration Agreements (Details) - Licensing Agreement - USD ($)	3 Months Ended	12 Months Ended
	Mar. 31, 2016	Dec. 31, 2015
Scripps Research Institute
License and Collaboration Agreements
Minimum annual fee		$ 25,000
Aggregate potential milestone payments	$ 2,600,000
Milestone payments made	$ 0
Period of written notice to terminate	90 days
Scripps Research Institute | Research and development
License and Collaboration Agreements
One-time cash payment		$ 10,000
Vernalis (R&D) Limited
License and Collaboration Agreements
Milestone payments made	$ 0
Period of written notice to terminate	90 days
Vernalis (R&D) Limited | Minimum
License and Collaboration Agreements
Aggregate potential milestone payments	$ 200,000,000
Vernalis (R&D) Limited | Research and development
License and Collaboration Agreements
One-time cash payment	$ 1,000,000

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