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Statements of Changes in Convertible Preferred Stock and Stockholders' Equity (Deficit) - USD ($) $ in Thousands | IPO Common Stock | IPO Additional Paid-In Capital | IPO | Convertible Preferred Stock. | Series A convertible preferred stock | Series B convertible preferred stock | Series A and Series B convertible preferred stock | Common Stock | Additional Paid-In Capital | Accumulated Other Comprehensive Income | Accumulated Deficit | Total
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Balance (in shares) at Dec. 31, 2014 |  |  |  | 3,395,468 |  |  |  | 1,046,749 |  |  |  |
Increase (Decrease) in Shares |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock to founders, net of repurchase (in shares) |  |  |  |  |  |  |  | 384,866 |  |  |  |
Issuance of stock (in shares) |  |  |  |  | 5,525,961 | 5,353,312 |  |  |  |  |  |
Balance (in shares) at Dec. 31, 2015 |  |  |  | 14,274,741 |  |  |  | 1,431,615 |  |  |  |
Increase (Decrease) in Convertible Preferred Stock |  |  |  |  |  |  |  |  |  |  |  |
Issuance of convertible preferred stock |  |  |  |  | $ 20,730 | $ 74,839 |  |  |  |  |  |
Reclassification of convertible preferred stock liability |  |  |  | $ 20,200 |  |  |  |  |  |  |  |
Balance at Dec. 31, 2015 |  |  |  | 125,780 | $ 50,941 | $ 74,839 |  |  |  |  |  | $ 125,780
Balance at Dec. 31, 2014 |  |  |  | $ 10,011 |  |  |  |  | $ 2 |  | $ (161) | (159)
Increase (Decrease) in Stockholders' Deficit |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock for cash upon early exercise of stock options and lapse of restrictions |  |  |  |  |  |  |  |  | 10 |  |  | 10
Stock-based compensation expense |  |  |  |  |  |  |  |  | 428 |  |  | 428
Unrealized loss on marketable securities |  |  |  |  |  |  |  |  |  | $ (45) |  | (45)
Net loss |  |  |  |  |  |  |  |  |  |  | (31,335) | (31,335)
Balance at Dec. 31, 2015 |  |  |  |  |  |  |  |  | 440 | (45) | (31,496) | (31,101)
Increase (Decrease) in Shares |  |  |  |  |  |  |  |  |  |  |  |
Number of common stock issued with the conversion of the preferred stock (in shares) |  |  |  |  |  |  | (14,274,741) | 14,274,741 |  |  |  |
Issuance of stock (in shares) | 5,202,618 |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock on exercise of stock options (in shares) |  |  |  |  |  |  |  | 13,454 |  |  |  |
Balance (in shares) at Dec. 31, 2016 |  |  |  |  |  |  |  | 20,922,428 |  |  |  |
Increase (Decrease) in Stockholders' Deficit |  |  |  |  |  |  |  |  |  |  |  |
Conversion of convertible preferred stock into common stock |  |  |  |  |  |  | $ (125,780) | $ 1 | 125,779 |  |  | 125,780
Issuance of common stock | $ 1 | $ 70,624 | $ 70,625 |  |  |  |  |  |  |  |  |
Common stock issued on exercise of stock options |  |  |  |  |  |  |  |  | 4 |  |  | 4
Vesting of restricted stocks issued upon early exercise of stock options |  |  |  |  |  |  |  |  | 34 |  |  | 34
Stock-based compensation expense |  |  |  |  |  |  |  |  | 3,828 |  |  | 3,828
Unrealized loss on marketable securities |  |  |  |  |  |  |  |  |  | 6 |  | 6
Net loss |  |  |  |  |  |  |  |  |  |  | (36,375) | (36,375)
Balance at Dec. 31, 2016 |  |  |  |  |  |  |  | $ 2 | $ 200,709 | $ (39) | $ (67,871) | $ 132,801

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