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Related Party Transactions - Additional Information (Details) - USD ($) |  | 3 Months Ended |
--- | --- | --- | ---
Jan. 23, 2026 | Mar. 31, 2026 | Mar. 31, 2025 | Dec. 31, 2025
Related Party Transaction [Line Items] |  |  |  |
Research and development |  | $ 11,175,000 | $ 7,453,000 |
Related party | Support clinical trials | ICON plc |  |  |  |
Related Party Transaction [Line Items] |  |  |  |
Research and development |  | $ 123,000 | $ 94,000 |
Angel Pharmaceuticals, Ltd |  |  |  |
Related Party Transaction [Line Items] |  |  |  |
Equity ownership interest | 49.70% | 49.70% |  | 49.70%
Follow-on Public Offering |  |  |  |
Related Party Transaction [Line Items] |  |  |  |
Common shares issued in transaction | 9,085,778 |  |  |
Share price of stock issued | $ 22.15 |  |  |
Follow-on Public Offering | Related party | Puissance Capital Management |  |  |  |
Related Party Transaction [Line Items] |  |  |  |
Common shares issued in transaction | 30,000 |  |  |
Share price of stock issued | $ 22.15 |  |  |

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