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Restructuring | 12 Months Ended
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Dec. 31, 2022
Restructuring and Related Activities [Abstract] |
Restructuring | 16. Restructuring On July 13, 2022, the Company announced a restructuring plan to prioritize its resources on its emerging pre-clinical and early clinical pipeline as well as its existing collaboration partnerships. The restructuring plan resulted in a reduction to its workforce of approximately 40%. Restructuring costs of $2.4 million and $5.3 million were recorded in general and administrative expense and research and development expense, respectively, for the year ended December 31, 2022. The following is a summary of accrued restructuring costs as of December 31, 2022 (in thousands):
|  | Severance and Benefits Costs |  |  | Contract Termination Cost |  |  | Stock Based Compensation |  |  | Total |
Total restructuring cost recorded |  | $ | 7,617 |  |  | $ | 178 |  |  | $ | 175 |  |  | $ | 7,970 |
Cash payment |  |  | (5,812 | ) |  |  | - |  |  |  | - |  |  |  | (5,812 | )
Change in estimates |  |  | (293 | ) |  |  | (14 | ) |  |  | - |  |  |  | (307 | )
Non-cash charges |  |  | - |  |  |  | - |  |  |  | (175 | ) |  |  | (175 | )
Balance at December 31, 2022 |  | $ | 1,512 |  |  | $ | 164 |  |  | $ | - |  |  | $ | 1,676 |
The total costs incurred in connection with the restructuring net of the changes in estimates related to certain voluntary departures of employees and reinstatement of employment, are approximately $7.7 millio n. The restructuring is substantially complete as of December 31, 2022 and the Company expects the remaining accrued restructuring costs will be paid in early 2023.

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- Definition The entire disclosure for restructuring and related activities. Description of restructuring activities such as exit and disposal activities, include facts and circumstances leading to the plan, the expected plan completion date, the major types of costs associated with the plan activities, total expected costs, the accrual balance at the end of the period, and the periods over which the remaining accrual will be settled. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 420 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SAB Topic 5.P.4(e)) -URI https://asc.fasb.org/extlink&oid=115931487&loc=d3e140904-122747 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 420 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (a) -URI https://asc.fasb.org/extlink&oid=6394359&loc=d3e17939-110869 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 420 -URI https://asc.fasb.org/topic&trid=2175745 Reference 4: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 420 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (e) -URI https://asc.fasb.org/extlink&oid=6394359&loc=d3e17939-110869 Reference 5: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 420 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b)(2) -URI https://asc.fasb.org/extlink&oid=6394359&loc=d3e17939-110869 + Details
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