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Statements of Stockholders' Equity (Deficit) - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid-in Capital
Accumulated Other Comprehensive Income/(Loss)
Accumulated Deficit
Beginning balance at Dec. 31, 2020 $ (7,774) $ 1 $ 499,964 $ (47) $ (507,692)
Beginning balance, shares at Dec. 31, 2020   48,251,819      
Exercise of stock options 1,428   1,428    
Exercise of stock options, shares   528,503      
Issuance of common stock under the Employee Stock Purchase Plan $ 1,073   1,073    
Issuance of common stock under the Employee Stock Purchase Plan, shares 183,865 183,865      
Issuance of common stock under the Open Market Sale Agreement and follow-on offering, net of issuance cost $ 107,712   107,712    
Issuance of common stock under the Open Market Sale Agreement and follow-on offering, net of issuance cost, shares   16,428,571      
Stock-based compensation 13,167   13,167    
Other comprehensive income (loss) (195)     (195)  
Net loss (115,870)       (115,870)
Ending balance at Dec. 31, 2021 (459) $ 1 623,344 (242) (623,562)
Ending balance, shares at Dec. 31, 2021   65,392,758      
Other comprehensive income (loss) (677)        
Net loss (31,981)        
Ending balance at Mar. 31, 2022 (29,739)        
Beginning balance at Dec. 31, 2021 (459) $ 1 623,344 (242) (623,562)
Beginning balance, shares at Dec. 31, 2021   65,392,758      
Other comprehensive income (loss) (920)        
Net loss (61,477)        
Ending balance at Jun. 30, 2022 (54,537)        
Beginning balance at Dec. 31, 2021 (459) $ 1 623,344 (242) (623,562)
Beginning balance, shares at Dec. 31, 2021   65,392,758      
Other comprehensive income (loss) (553)        
Net loss (90,541)        
Ending balance at Sep. 30, 2022 (80,539)        
Beginning balance at Dec. 31, 2021 $ (459) $ 1 623,344 (242) (623,562)
Beginning balance, shares at Dec. 31, 2021   65,392,758      
Exercise of stock options, shares 102,221        
Exercise of stock options and release of RSUs $ 99   99    
Exercise of stock options and release of RSUs, shares   430,096      
Issuance of common stock under the Employee Stock Purchase Plan $ 549   549    
Issuance of common stock under the Employee Stock Purchase Plan, shares 405,192 405,192      
Stock-based compensation $ 13,125   13,125    
Other comprehensive income (loss) 252     252  
Net loss (99,317)       (99,317)
Ending balance at Dec. 31, 2022 (85,751) $ 1 $ 637,117 $ 10 $ (722,879)
Ending balance, shares at Dec. 31, 2022   66,228,046      
Beginning balance at Mar. 31, 2022 (29,739)        
Other comprehensive income (loss) (243)        
Net loss (29,496)        
Ending balance at Jun. 30, 2022 (54,537)        
Other comprehensive income (loss) 367        
Net loss (29,064)        
Ending balance at Sep. 30, 2022 $ (80,539)