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Collaboration and License Agreements - Astellas Pharma Inc - Additional Information (Details) $ in Thousands	Mar. 23, 2020 USD ($) Target	Dec. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Deferred revenue		$ 301,326	$ 284,760	$ 318,707
Astellas Pharma Inc.
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Deferred revenue		44,500
Collaboration and License Agreement | Astellas Pharma Inc.
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Number of targets selected | Target	1
Number of additional collaboration target | Target	3
Upfront payment received	$ 80,000
Total transaction price	103,200
Research and development service fees	23,200
Deferred revenue		44,500	60,300
Amount due from customer		$ 1,000	$ 800
Collaboration and License Agreement | Astellas Pharma Inc. | Additional Contingent Payments
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Contingent milestone payments receivable	$ 900,000
Collaboration and License Agreement | Astellas Pharma Inc. | Maximum
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Number of targets | Target	4
Right to expand the number of additional collaboration target | Target	5
Contingent milestone payments receivable	$ 1,600,000
Collaboration and License Agreement | Astellas Pharma Inc. | Minimum
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Right to expand the number of additional collaboration target | Target	3

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