<SEC-DOCUMENT>0001610717-25-000369.txt : 20251029
<SEC-HEADER>0001610717-25-000369.hdr.sgml : 20251029
<ACCEPTANCE-DATETIME>20251029164949
ACCESSION NUMBER:		0001610717-25-000369
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20251020
FILED AS OF DATE:		20251029
DATE AS OF CHANGE:		20251029

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Lester Rachael
		CENTRAL INDEX KEY:			0002094324
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-37587
		FILM NUMBER:		251430646

	MAIL ADDRESS:	
		STREET 1:		C/O CYTOMX THERAPEUTICS, INC.
		STREET 2:		151 OYSTER POINT BLVD., SUITE 400
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CytomX Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001501989
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				273521219
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		151 OYSTER POINT BLVD.
		STREET 2:		SUITE 400
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
		BUSINESS PHONE:		650.515.3185

	MAIL ADDRESS:	
		STREET 1:		151 OYSTER POINT BLVD.
		STREET 2:		SUITE 400
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>form3.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2025-10-20</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001501989</issuerCik>
        <issuerName>CytomX Therapeutics, Inc.</issuerName>
        <issuerTradingSymbol>CTMX</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0002094324</rptOwnerCik>
            <rptOwnerName>Lester Rachael</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CYTOMX THERAPEUTICS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>151 OYSTER POINT BLVD., SUITE 400</rptOwnerStreet2>
            <rptOwnerCity>SOUTH SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94080</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isOfficer>true</isOfficer>
            <officerTitle>Chief Business Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <remarks>Exhibit 24.1 - Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>/s/ Christopher Ogden, as Attorney-in-Fact for Rachael Lester</signatureName>
        <signatureDate>2025-10-29</signatureDate>
    </ownerSignature>
</ownershipDocument>
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</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-24.1
<SEQUENCE>2
<FILENAME>poa.htm
<DESCRIPTION>POWER OF ATTORNEY
<TEXT>
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    <title></title>
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  <div>
    <div style="text-align: center; font-variant: small-caps; font-weight: bold;">SECTION 16 AND FORM 144<br>
      POWER OF ATTORNEY</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;">With respect to holdings of and transactions in securities
        issued by CytomX Therapeutics, Inc. (the &#8220;<font style="font-weight: bold; font-style: italic;">Company</font>&#8221;), the undersigned hereby constitutes and appoints the individuals named on <font style="font-weight: bold;"><u>Schedule A</u></font> attached hereto and as may be amended from time to time, or any of them signing singly, with full power of substitution and resubstitution, to act as the undersigned&#8217;s true and lawful attorney-in-fact
        to:</div>
    <div><br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" id="zf7e2dbd6c97e457b936f30c9fb6b3948" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 63pt; vertical-align: top; text-align: right;">
              <div style="text-align: left; margin-left: 36pt;">1.</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;">execute for and on behalf of the undersigned, Schedules 13D and 13G in accordance with Section 13 of the Securities Exchange Act of 1934, as
                amended (the &#8220;<font style="font-weight: bold; font-style: italic;">Exchange Act</font>&#8221;), and the rules thereunder, and Forms 3, 4, and 5 in accordance with Section 16 of the
                Exchange Act and the rules thereunder, and Notices of Proposed Sale of Securities Pursuant to Rule 144 (<font style="font-weight: bold; font-style: italic;">&#8220;Form 144&#8221;</font>),
                in accordance with the requirements of Rule 144 under the Securities Act of 1933, as amended (the &#8220;<font style="font-weight: bold; font-style: italic;">Securities Act</font>&#8221;);
                and</div>
            </td>
          </tr>

      </table>
    </div>
    <div><br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" id="zcb6d707e73f3423ba1db48da0e2328c7" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 63pt; vertical-align: top; text-align: right;">
              <div style="text-align: left; margin-left: 36pt;">2.</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="text-align: justify;">do and perform any and all acts for and on behalf of the undersigned which may be necessary or desirable to complete and execute any such
                Schedule 13D, Schedule 13G, Form 3, Form 4, Form 5, and Form 144, complete and execute any amendment or amendments thereto, and to timely file such Schedule 13D, Schedule 13G, Form 3, Form 4, Form 5, and Form 144, as applicable, and any
                amendment thereto, with the United States Securities and Exchange Commission&#160; and any stock exchange or similar authority.</div>
            </td>
          </tr>

      </table>
    </div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;">The undersigned hereby grants to each such attorney-in-fact full power and authority to do and perform any and every act and thing
      whatsoever requisite, necessary, or proper to be done in the exercise of any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned might or could do if personally present, with full power of substitution and
      resubstitution or revocation, hereby ratifying and confirming all that such attorney-in-fact, or such attorneys-in-fact substitute or substitutes, shall lawfully do or cause to be done by virtue of this Power of Attorney and the rights and powers
      herein granted.</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;">The undersigned acknowledges that the foregoing attorneys-in-fact, in serving in such capacity at the request of the undersigned, are
      not assuming, nor is the Company assuming, any of the undersigned&#8217;s responsibilities to comply with Section 13 and Section 16 of the Exchange Act, or Rule 144 under the Securities Act.</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;">This Power of Attorney shall remain in full force and effect until the undersigned is no longer required to file any Schedule
      13D,Schedule 13G, Form 3, Form 4, Form 5, and Form 144 with respect to the undersigned&#8217;s holdings of and transactions in securities issued by the Company, unless earlier revoked by the undersigned in a signed writing delivered to the foregoing
      attorneys-in-fact.</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;">IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be executed as of this 24th day of October, 2025.</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="text-align: justify; margin-left: 288pt;"><u>/s/ Rachael Lester</u><font class="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 180pt">&#160;</font></div>
    <div style="text-align: justify; margin-left: 288pt;">Rachael Lester</div>
    <div><br>
    </div>
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    </div>
    <div style="text-align: center;"><u>Schedule A</u></div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">INDIVIDUALS APPOINTED AS ATTORNEY-IN-FACT,</div>
    <div style="text-align: center; font-weight: bold;">WITH FULL POWER OF SUBSTITUTION AND RESUBSTITUTION</div>
    <div><br>
    </div>
    <div style="text-align: justify;">1.<font class="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 36pt">&#160;</font>Sean A. McCarthy, Chief Executive Officer of the Company</div>
    <div style="text-align: justify;">2.<font class="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 36pt">&#160;</font>Chris Ogden, Chief Financial Officer of the Company</div>
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</TEXT>
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