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Share-based payments - Share options outstanding (Details) - EMI share option scheme
6 Months Ended 12 Months Ended
Jun. 30, 2022
Options
£ / shares
Dec. 31, 2021
Options
£ / shares
Dec. 31, 2020
Options
£ / shares
Outstanding share options      
Weighted average exercise price £ 0.19 £ 308.06 £ 143.28
Number of share options outstanding | Options 21,656,655 19,670 16,817
Expected weighted average remaining vesting period (years) 2 years 7 months 20 days 1 year 1 month 13 days  
Number of options exercisable | Options 9,594,507 7,715  
Minimum      
Outstanding share options      
Exercise prices £ 0.03    
Maximum      
Outstanding share options      
Exercise prices £ 1.18