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Share-based payments - Share options outstanding (Details)
12 Months Ended
Dec. 31, 2021
Options
£ / shares
Dec. 31, 2020
Options
£ / shares
Disclosure of terms and conditions of share-based payment arrangement [line items]    
Weighted average exercise price £ 308.06 £ 143.28
Number of share options outstanding | Options 19,670 16,817
Expected weighted average remaining vesting period (years) 1 year 1 month 13 days 1 year 1 month 17 days
Number of options exercisable | Options 7,715 7,635
Maximum    
Disclosure of terms and conditions of share-based payment arrangement [line items]    
Exercise prices £ 1,298.49  
Minimum    
Disclosure of terms and conditions of share-based payment arrangement [line items]    
Exercise prices £ 38.22