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Significant agreements - AstraZeneca Collaboration Agreement (Details) | 1 Months Ended | 3 Months Ended | 9 Months Ended |  |  |  |
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May 31, 2019 employee | May 31, 2018 USD ($) | Mar. 31, 2018 USD ($) | Aug. 31, 2017 | Nov. 30, 2016 USD ($) employee item | Sep. 30, 2020 USD ($) | Sep. 30, 2019 USD ($) | Sep. 30, 2020 USD ($) | Sep. 30, 2019 USD ($) | Dec. 31, 2019 USD ($) | Jul. 31, 2019 USD ($) | Dec. 31, 2018 USD ($) | Oct. 31, 2017 USD ($)
Significant agreements. |  |  |  |  |  |  |  |  |  |  |  |  |
Collaboration revenues |  |  |  |  |  | $ 3,842,000 | $ 614,000 | $ 6,542,000 | $ 8,520,000 |  |  |  |
Deferred revenue |  |  |  |  |  | 33,275,000 |  | 33,275,000 |  | $ 5,657,000 |  | $ 14,635,000 |
AstraZeneca |  |  |  |  |  |  |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |  |  |  |  |  |  |
Biological Targets | item |  |  |  |  | 6 |  |  |  |  |  |  |  |
Term (in years) |  |  |  | 3 years |  |  |  |  |  |  |  |  |
Term, Bicycle Research Team (in years) |  |  |  |  | 1 year |  |  |  |  |  |  |  |
Term, AZ Research (in years) |  |  |  |  | 2 years |  |  |  |  |  |  |  |
Number of FTE | employee |  |  |  |  | 2 |  |  |  |  |  |  |  |
Collaboration revenues |  |  |  |  |  | 213,000 | 441,000 | 944,000 | 1,229,000 |  |  |  |
Deferred revenue |  |  |  |  |  | 5,090,000 |  | 5,090,000 |  | 4,913,000 |  | $ 4,727,000 |
AstraZeneca | Development milestone |  |  |  |  |  |  |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |  |  |  |  |  |  |
Transaction price |  | $ 700,000 |  |  |  |  |  |  |  |  |  |  |
AstraZeneca | Target One |  |  |  |  |  |  |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |  |  |  |  |  |  |
Transaction price |  |  |  |  |  |  |  |  |  |  |  |  | $ 2,000,000
AstraZeneca | Target Two |  |  |  |  |  |  |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |  |  |  |  |  |  |
Transaction price |  |  |  |  | $ 600,000 |  |  |  |  |  |  |  |
AstraZeneca | Target Three Research License and Related Services |  |  |  |  |  |  |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |  |  |  |  |  |  |
Collaboration revenues |  |  |  |  |  | 200,000 | 400,000 | 900,000 | 1,000,000 |  |  |  |
AstraZeneca | Commercialization license per candidate |  |  |  |  |  |  |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |  |  |  |  |  |  |
Customer option payment |  |  |  |  | 8,000,000 |  |  |  |  |  |  |  |
AstraZeneca | Development Milestone | Development milestone |  |  |  |  |  |  |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |  |  |  |  |  |  |
Customer option payment |  |  |  |  | 29,000,000 |  |  |  |  |  |  |  |
AstraZeneca | Regulatory Milestone | Regulatory milestone |  |  |  |  |  |  |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |  |  |  |  |  |  |
Customer option payment |  |  |  |  | 23,000,000 |  |  |  |  |  |  |  |
AstraZeneca | Commercial milestone | Commercial milestone |  |  |  |  |  |  |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |  |  |  |  |  |  |
Customer option payment |  |  |  |  | $ 110,000,000 |  |  |  |  |  |  |  |
AstraZeneca | Minimum |  |  |  |  |  |  |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |  |  |  |  |  |  |
Term extension (in years) |  |  |  |  | 12 months |  |  |  |  |  |  |  |
AstraZeneca | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |  |  |  |  |  |  |
Term extension (in years) |  |  |  |  | 15 months |  |  |  |  |  |  |  |
AstraZeneca | 2016 Collaboration Agreement |  |  |  |  |  |  |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |  |  |  |  |  |  |
Biological Targets | item |  |  |  |  | 2 |  |  |  |  |  |  |  |
Option fee for development and exploitation rights |  |  |  |  | $ 8,000,000 |  |  |  |  |  |  |  |
Transaction price |  |  |  |  | $ 1,200,000 |  |  |  |  |  |  |  |
Deferred revenue |  |  |  |  |  | 0 |  | 0 |  | 0 |  |  |
AstraZeneca | 2016 Collaboration Agreement | Target One and Target Two Research License and Related Services |  |  |  |  |  |  |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |  |  |  |  |  |  |
Collaboration revenues |  |  |  |  |  | 0 | $ 0 | 0 | $ 200,000 |  |  |  |
AstraZeneca | May 2018 Option Exercise |  |  |  |  |  |  |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |  |  |  |  |  |  |
Biological Targets | item |  |  |  |  | 4 |  |  |  |  |  |  |  |
Option fee for development and exploitation rights |  | 5,000,000 | $ 5,000,000 |  | $ 5,000,000 |  |  |  |  |  |  |  |
Number of FTE | employee | 2 |  |  |  |  |  |  |  |  |  |  |  |
Customer option payment |  | $ 8,000,000 |  |  |  |  |  |  |  |  |  |  |
Transaction price |  |  |  |  |  | 5,650,000 |  | 5,650,000 |  |  | $ 6,300,000 |  |
Deferred revenue |  |  |  |  |  | 5,100,000 |  | 5,100,000 |  | $ 4,900,000 |  |  |
AstraZeneca | May 2018 Option Exercise | Target Three Research License and Related Services |  |  |  |  |  |  |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |  |  |  |  |  |  |
Transaction price |  |  |  |  |  | 650,000 |  | 650,000 |  |  |  |  |
AstraZeneca | May 2018 Option Exercise | Target 3 Material Right |  |  |  |  |  |  |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |  |  |  |  |  |  |
Transaction price |  |  |  |  |  | 1,504,000 |  | 1,504,000 |  |  |  |  |
AstraZeneca | May 2018 Option Exercise | Target 4 Material Right |  |  |  |  |  |  |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |  |  |  |  |  |  |
Transaction price |  |  |  |  |  | 1,204,000 |  | 1,204,000 |  |  |  |  |
AstraZeneca | May 2018 Option Exercise | Target 5 Material Right |  |  |  |  |  |  |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |  |  |  |  |  |  |
Transaction price |  |  |  |  |  | 1,165,000 |  | 1,165,000 |  |  |  |  |
AstraZeneca | May 2018 Option Exercise | Target 6 Material Right |  |  |  |  |  |  |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |  |  |  |  |  |  |
Transaction price |  |  |  |  |  | $ 1,127,000 |  | $ 1,127,000 |  |  |  |  |

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