    <SEC-DOCUMENT>0001104659-20-070493-index.html : 20200605
    <SEC-HEADER>0001104659-20-070493.hdr.sgml : 20200605
    <ACCEPTANCE-DATETIME>20200605172806
    ACCESSION NUMBER:		0001104659-20-070493
    CONFORMED SUBMISSION TYPE:	S-3
    PUBLIC DOCUMENT COUNT:		13
    FILED AS OF DATE:		20200605
    DATE AS OF CHANGE:		20200605

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			BICYCLE THERAPEUTICS plc
    		CENTRAL INDEX KEY:			0001761612
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				000000000

    	FILING VALUES:
    		FORM TYPE:		S-3
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-238996
    		FILM NUMBER:		20947425

    	BUSINESS ADDRESS:
    		STREET 1:		B900 BABRAHAM RESEARCH CAMPUS
    		CITY:			CAMBRIDGE
    		STATE:			X0
    		ZIP:			CB22 3AT
    		BUSINESS PHONE:		011441223261503

    	MAIL ADDRESS:
    		STREET 1:		B900 BABRAHAM RESEARCH CAMPUS
    		CITY:			CAMBRIDGE
    		STATE:			X0
    		ZIP:			CB22 3AT

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	BICYCLE THERAPEUTICS Ltd
    		DATE OF NAME CHANGE:	20181212
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>S-3
    <SEQUENCE>1
    <FILENAME>tm2021794-1_s3.htm
    <DESCRIPTION>S-3
    <TEXT>
    Document 1 - file: tm2021794-1_s3.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-1.2
    <SEQUENCE>2
    <FILENAME>tm2021794d2_ex1-2.htm
    <DESCRIPTION>EXHIBIT 1.2
    <TEXT>
    Document 2 - file: tm2021794d2_ex1-2.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-4.4
    <SEQUENCE>3
    <FILENAME>tm2021794d2_ex4-4.htm
    <DESCRIPTION>EXHIBIT 4.4
    <TEXT>
    Document 3 - file: tm2021794d2_ex4-4.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-4.5
    <SEQUENCE>4
    <FILENAME>tm2021794d2_ex4-5.htm
    <DESCRIPTION>EXHIBIT 4.5
    <TEXT>
    Document 4 - file: tm2021794d2_ex4-5.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-4.7
    <SEQUENCE>5
    <FILENAME>tm2021794d2_ex4-7.htm
    <DESCRIPTION>EXHIBIT 4.7
    <TEXT>
    Document 5 - file: tm2021794d2_ex4-7.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-4.8
    <SEQUENCE>6
    <FILENAME>tm2021794d2_ex4-8.htm
    <DESCRIPTION>EXHIBIT 4.8
    <TEXT>
    Document 6 - file: tm2021794d2_ex4-8.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-4.9
    <SEQUENCE>7
    <FILENAME>tm2021794d2_ex4-9.htm
    <DESCRIPTION>EXHIBIT 4.9
    <TEXT>
    Document 7 - file: tm2021794d2_ex4-9.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-5.1
    <SEQUENCE>8
    <FILENAME>tm2021794d2_ex5-1.htm
    <DESCRIPTION>EXHIBIT 5.1
    <TEXT>
    Document 8 - file: tm2021794d2_ex5-1.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-5.2
    <SEQUENCE>9
    <FILENAME>tm2021794d2_ex5-2.htm
    <DESCRIPTION>EXHIBIT 5.2
    <TEXT>
    Document 9 - file: tm2021794d2_ex5-2.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-23.1
    <SEQUENCE>10
    <FILENAME>tm2021794d2_ex23-1.htm
    <DESCRIPTION>EXHIBIT 23.1
    <TEXT>
    Document 10 - file: tm2021794d2_ex23-1.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>11
    <FILENAME>lg_bicycle-4c.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 11 - file: lg_bicycle-4c.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>12
    <FILENAME>tm2021794d2_ex5-1img01.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 12 - file: tm2021794d2_ex5-1img01.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>13
    <FILENAME>tm2021794d2_ex5-2img001.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 13 - file: tm2021794d2_ex5-2img001.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>