    <SEC-DOCUMENT>0001558370-23-007268-index.html : 20230428
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    <ACCEPTANCE-DATETIME>20230428160648
    ACCESSION NUMBER:		0001558370-23-007268
    CONFORMED SUBMISSION TYPE:	DEF 14A
    PUBLIC DOCUMENT COUNT:		18
    CONFORMED PERIOD OF REPORT:	20230613
    FILED AS OF DATE:		20230428
    DATE AS OF CHANGE:		20230428

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			BICYCLE THERAPEUTICS plc
    		CENTRAL INDEX KEY:			0001761612
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				000000000

    	FILING VALUES:
    		FORM TYPE:		DEF 14A
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-38916
    		FILM NUMBER:		23865979

    	BUSINESS ADDRESS:
    		STREET 1:		BLOCKS A & B, PORTWAY BUILDING
    		STREET 2:		GRANTA PARK, GREAT ABINGTON
    		CITY:			CAMBRIDGE
    		STATE:			X0
    		ZIP:			CB21 6GS
    		BUSINESS PHONE:		011441223261503

    	MAIL ADDRESS:
    		STREET 1:		BLOCKS A & B, PORTWAY BUILDING
    		STREET 2:		GRANTA PARK, GREAT ABINGTON
    		CITY:			CAMBRIDGE
    		STATE:			X0
    		ZIP:			CB21 6GS

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	BICYCLE THERAPEUTICS Ltd
    		DATE OF NAME CHANGE:	20181212
    </SEC-HEADER>
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