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Significant agreements - Novartis Collaboration Agreement (Details) $ in Thousands |  | 3 Months Ended | 9 Months Ended |  |
--- | --- | --- | --- | --- | ---
Mar. 27, 2023 USD ($) item | Sep. 30, 2024 USD ($) | Sep. 30, 2023 USD ($) | Sep. 30, 2024 USD ($) | Sep. 30, 2023 USD ($) | Dec. 31, 2023 USD ($) | Dec. 31, 2022 USD ($)
Significant agreements. |  |  |  |  |  |  |
Maximum days allowed for cancellation of contracts prior written notice |  |  |  | 90 days |  |  |
Revenue from collaborative arrangement |  | $ 2,676 | $ 5,352 | $ 31,567 | $ 21,645 |  |
Deferred revenue |  | 109,191 |  | 109,191 |  | $ 135,194 | $ 61,873
Termination in entirety or product by product or target by target basis |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |
Threshold period of notice required for termination of agreement | 90 days |  |  |  |  |  |
Completion of all milestones for targets |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |
Milestone payments receivable | $ 800,000 |  |  |  |  |  |
Novartis |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |
Number of collaboration targets | item | 2 |  |  |  |  |  |
Additional research term | 1 year |  |  |  |  |  |
Upfront cash payment | $ 50,000 |  |  |  |  |  |
Milestone payments receivable | 210,000 |  |  |  |  |  |
Milestone payments, receivable | $ 840,000 |  |  |  |  |  |
Maximum days allowed for cancellation of contracts prior written notice | 30 days |  |  |  |  |  |
Total transaction price initially determined | $ 50,000 |  |  |  |  |  |
Expected period for satisfaction of performance obligations | 3 years |  |  |  |  |  |
Material rights exercise period | 6 years |  |  |  |  |  |
Revenue from collaborative arrangement |  | 1,276 | $ 772 | 6,301 | $ 772 |  |
Deferred revenue |  | 45,971 |  | $ 45,971 |  | $ 50,008 | $ 0
Novartis | Termination based on other party's uncured material breach or insolvency |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |
Threshold period of notice required for termination of agreement | 60 days |  |  |  |  |  |
Novartis | Termination if safety or regulatory issue exists |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |
Threshold period of notice required for termination of agreement | 30 days |  |  |  |  |  |
Novartis | Expiration of two material rights associated with limited substitution rights |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |
Revenue from collaborative arrangement |  | $ 2,500 |  |  |  |  |
Novartis | Achievement of specified levels of net sales |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |
Milestone payments receivable | $ 200,000 |  |  |  |  |  |

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