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Significant agreements - Ionis Accounting Analysis (Details) $ in Thousands |  | 1 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended |  |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Jul. 09, 2021 USD ($) item | Oct. 31, 2022 USD ($) | Dec. 31, 2021 USD ($) | Jan. 31, 2021 USD ($) | Sep. 30, 2024 USD ($) | Sep. 30, 2023 USD ($) | Sep. 30, 2024 USD ($) item | Sep. 30, 2023 USD ($) | Dec. 31, 2020 USD ($) | Mar. 31, 2024 USD ($) | Mar. 30, 2024 USD ($) | Dec. 31, 2023 USD ($) | Dec. 31, 2022 USD ($)
Significant agreements. |  |  |  |  |  |  |  |  |  |  |  |  |
Collaboration revenues |  |  |  |  | $ 2,676 | $ 5,352 | $ 31,567 | $ 21,645 |  |  |  |  |
Deferred revenue |  |  |  |  | 109,191 |  | $ 109,191 |  |  |  |  | $ 135,194 | $ 61,873
Ionis |  |  |  |  |  |  |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |  |  |  |  |  |  |
Number of material rights associated with future payments | item |  |  |  |  |  |  | 4 |  |  |  |  |  |
Number of collaboration targets | item | 4 |  |  |  |  |  |  |  |  |  |  |  |
Transaction price | $ 38,000 |  |  |  |  |  |  |  |  | $ 37,800 |  |  |
Upfront cash payment | 31,000 |  |  |  |  |  |  |  |  |  |  |  |
Estimated amount payable to CROs | 600 |  |  |  |  |  |  |  |  | $ 400 | $ 600 |  |
Material rights exercise period |  |  |  |  |  |  | 4 years |  |  |  |  |  |
Collaboration revenues |  |  |  |  | 0 | $ 2,782 | $ 8,881 | $ 8,123 |  |  |  |  |
Deferred revenue |  |  |  |  | 3,801 |  | 3,801 |  |  |  |  | 12,464 | $ 21,489
Ionis | Combined licenses and research and discovery performance obligation |  |  |  |  |  |  |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |  |  |  |  |  |  |
Transaction price | 34,100 |  |  |  |  |  |  |  |  |  |  |  |
Ionis | Four material rights associated with credits for IND Acceptance fees |  |  |  |  |  |  |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |  |  |  |  |  |  |
Transaction price | 3,900 |  |  |  |  |  |  |  |  |  |  |  |
Ionis | Ionis Share Purchase Agreement |  |  |  |  |  |  |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |  |  |  |  |  |  |
Transaction price | 3,400 |  |  |  |  |  |  |  |  |  |  |  |
Ionis Evaluation and Option Agreement |  |  |  |  |  |  |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront cash payment | $ 3,000 |  |  | $ 3,000 |  |  |  |  | $ 3,000 |  |  |  |
Deferred revenue |  |  |  |  | $ 3,800 |  | 3,800 |  | $ 3,000 |  |  | $ 12,500 |
Amended Ionis |  |  |  |  |  |  |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront cash payment |  |  | $ 1,600 |  |  |  |  |  |  |  |  |  |
Collaboration revenues |  | $ 800 | $ 800 |  |  |  |  |  |  |  |  |  |
Third Amended Ionis |  |  |  |  |  |  |  |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |  |  |  |  |  |  |  |
Collaboration revenues |  |  |  |  |  |  | $ 800 |  |  |  |  |  |

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