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Significant agreements - Ionis Collaboration Agreement (Details) $ in Millions |  | 1 Months Ended
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Jul. 09, 2021 USD ($) item | Apr. 30, 2023 USD ($) | Oct. 31, 2022 USD ($) | Aug. 31, 2022 USD ($) | Dec. 31, 2021 USD ($)
Ionis |  |  |  |  |
Significant agreements. |  |  |  |  |
Period for which research and discovery activities will be performed with no additional consideration | 3 years |  |  |  |
Upfront cash payment | $ 31.0 |  |  |  |
Number of payments of a mid-single-digit million dollar, failing to achieve the specified development diligence | item | 3 |  |  |  |
Number of collaboration targets | item | 4 |  |  |  |
Number of years over which royalty is payable | 10 years |  |  |  |
Amended Ionis |  |  |  |  |
Significant agreements. |  |  |  |  |
Upfront cash payment |  |  |  |  | $ 1.6
Amended Ionis | Service for initial six month |  |  |  |  |
Significant agreements. |  |  |  |  |
Upfront cash payment |  |  |  | $ 0.8 |
Amended Ionis | Service for additional six month |  |  |  |  |
Significant agreements. |  |  |  |  |
Upfront cash payment |  |  | $ 0.8 |  |
Third Ionis Amendment |  |  |  |  |
Significant agreements. |  |  |  |  |
Upfront cash payment |  | $ 0.8 |  |  |
Third Ionis Amendment | Additional research service for a year |  |  |  |  |
Significant agreements. |  |  |  |  |
Upfront cash payment |  | $ 0.8 |  |  |

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- Definition Number of collaboration targets under the collaboration agreement. + References No definition available. + Details
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- Definition The amount of upfront cash payment received from collaborative arrangement. + References No definition available. + Details
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- Definition The number of payments of a mid-single-digit million dollar, failing to achieve the specified development diligence. + References No definition available. + Details
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- Definition Represents number of years over which royalty is payable. + References No definition available. + Details
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- Definition Period for which the company will perform research and discovery activities including a baseline level of effort for no additional consideration, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days. + References No definition available. + Details
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- Definition Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 808 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 1 -Subparagraph (d) -Publisher FASB -URI https://asc.fasb.org/1943274/2147479402/808-10-50-1 + Details
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- Details
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- Details
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- Details
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- Details
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- Details
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- Details
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