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Significant agreements - Ionis Evaluation and Option Agreement (Details) - USD ($) $ in Thousands |  | 1 Months Ended | 12 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | ---
Jul. 09, 2021 | Jan. 31, 2021 | Dec. 31, 2020 | Sep. 30, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Significant agreements. |  |  |  |  |  |
Deferred revenue |  |  |  | $ 109,191 | $ 135,194 | $ 61,873
Ionis Evaluation and Option Agreement |  |  |  |  |  |
Significant agreements. |  |  |  |  |  |
Upfront cash payment | $ 3,000 | $ 3,000 | $ 3,000 |  |  |
Deferred revenue |  |  | $ 3,000 | $ 3,800 | $ 12,500 |

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