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Nature of the business and basis of presentation - Liquidity (Details)
$ / shares in Units, $ in Thousands
 3 Months Ended 9 Months Ended
May 28, 2024
USD ($)
May 23, 2024
£ / shares
shares
Jul. 17, 2023
USD ($)
shares
Sep. 30, 2024
USD ($)
shares
Jun. 30, 2024
USD ($)
Mar. 31, 2024
USD ($)
Sep. 30, 2023
USD ($)
shares
Jun. 30, 2023
USD ($)
Mar. 31, 2023
USD ($)
Sep. 30, 2024
USD ($)
shares
Sep. 30, 2023
USD ($)
shares
Sep. 30, 2024
£ / shares
May 23, 2024
$ / shares
Dec. 31, 2023
USD ($)
Dec. 31, 2023
£ / shares
Jul. 17, 2023
£ / shares
Jul. 17, 2023
$ / shares
Cash and cash equivalents       $ 890,862     $ 572,086     $ 890,862 $ 572,086     $ 526,423      
Ordinary shares, nominal value | £ / shares                       £ 0.01     £ 0.01    
Gross proceeds before discounts and commissions         $ 544,127   234,492 $ 12,127 $ 2,716                
Proceeds from the issuance, net of issuance costs                   544,127 249,335            
Net Income (Loss)       (50,802) $ (39,812) $ (26,563) $ (49,898) $ (42,603) $ (39,064) (117,177) $ (131,565)            
Accumulated deficit       $ (628,937)           $ (628,937)       $ (511,760)      
At the market offering | American Depositary Shares                                  
Shares issued (in shares) | shares       0     941,176     0 1,561,176            
Gross proceeds before discounts and commissions             $ 20,000       $ 35,300            
Proceeds from the issuance, net of issuance costs             19,400       34,200            
Commissions and offering expenses             $ 600       $ 1,100            
Purchase Agreement                                  
Gross proceeds before discounts and commissions $ 555,500   $ 230,000                            
Proceeds from the issuance, net of issuance costs 544,100   215,100                            
Commissions and offering expenses $ 11,400   $ 14,900                            
Purchase Agreement | American Depositary Shares                                  
Shares issued (in shares) | shares   6,764,705 6,117,648                            
Ordinary shares, nominal value | £ / shares   £ 0.01                           £ 0.01  
Share issue price | $ / shares                         $ 21.42       $ 21.25
Purchase Agreement | Non voting ordinary shares                                  
Shares issued (in shares) | shares   19,169,001 4,705,882                            
Ordinary shares, nominal value | £ / shares   £ 0.01                           £ 0.01  
Purchase Agreement | Underwritten Public Offering | American Depositary Shares                                  
Shares issued (in shares) | shares     1,411,764