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Significant agreements - Ionis Evaluation and Option Agreement (Details) - USD ($) $ in Thousands		1 Months Ended	12 Months Ended
	Jul. 09, 2021	Jan. 31, 2021	Dec. 31, 2020	Sep. 30, 2024	Dec. 31, 2023	Dec. 31, 2022
Significant agreements.
Deferred revenue				$ 109,191	$ 135,194	$ 61,873
Ionis Evaluation and Option Agreement
Significant agreements.
Upfront cash payment	$ 3,000	$ 3,000	$ 3,000
Deferred revenue			$ 3,000	$ 3,800	$ 12,500

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- Definition

The amount of upfront cash payment received from collaborative arrangement.

+ References

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- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 808
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 1
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- Definition

Amount of obligation to transfer good or service to customer for which consideration has been received or is receivable.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
-Section 45
-Paragraph 1
-Publisher FASB
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Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
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-Topic 606
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