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Significant agreements - Ionis Collaboration Agreement (Details)
$ in Millions
1 Months Ended
Jul. 09, 2021
USD ($)
item
Apr. 30, 2023
USD ($)
Oct. 31, 2022
USD ($)
Aug. 31, 2022
USD ($)
Dec. 31, 2021
USD ($)
Ionis          
Significant agreements.          
Period for which research and discovery activities will be performed with no additional consideration 3 years        
Upfront cash payment $ 31.0        
Number of payments of a mid-single-digit million dollar, failing to achieve the specified development diligence | item 3        
Number of collaboration targets | item 4        
Number of years over which royalty is payable 10 years        
Amended Ionis          
Significant agreements.          
Upfront cash payment         $ 1.6
Amended Ionis | Service for initial six month          
Significant agreements.          
Upfront cash payment       $ 0.8  
Amended Ionis | Service for additional six month          
Significant agreements.          
Upfront cash payment     $ 0.8    
Third Ionis Amendment          
Significant agreements.          
Upfront cash payment   $ 0.8      
Third Ionis Amendment | Additional research service for a year          
Significant agreements.          
Upfront cash payment   $ 0.8