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Significant agreements - Ionis Accounting Analysis (Details) $ in Thousands		1 Months Ended			3 Months Ended		9 Months Ended		12 Months Ended
	Jul. 09, 2021 USD ($) item	Oct. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)	Jan. 31, 2021 USD ($)	Sep. 30, 2024 USD ($)	Sep. 30, 2023 USD ($)	Sep. 30, 2024 USD ($) item	Sep. 30, 2023 USD ($)	Dec. 31, 2020 USD ($)	Mar. 31, 2024 USD ($)	Mar. 30, 2024 USD ($)	Dec. 31, 2023 USD ($)	Dec. 31, 2022 USD ($)
Significant agreements.
Collaboration revenues					$ 2,676	$ 5,352	$ 31,567	$ 21,645
Deferred revenue					109,191		$ 109,191					$ 135,194	$ 61,873
Ionis
Significant agreements.
Number of material rights associated with future payments | item							4
Number of collaboration targets | item	4
Transaction price	$ 38,000									$ 37,800
Upfront cash payment	31,000
Estimated amount payable to CROs	600									$ 400	$ 600
Material rights exercise period							4 years
Collaboration revenues					0	$ 2,782	$ 8,881	$ 8,123
Deferred revenue					3,801		3,801					12,464	$ 21,489
Ionis | Combined licenses and research and discovery performance obligation
Significant agreements.
Transaction price	34,100
Ionis | Four material rights associated with credits for IND Acceptance fees
Significant agreements.
Transaction price	3,900
Ionis | Ionis Share Purchase Agreement
Significant agreements.
Transaction price	3,400
Ionis Evaluation and Option Agreement
Significant agreements.
Upfront cash payment	$ 3,000			$ 3,000					$ 3,000
Deferred revenue					$ 3,800		3,800		$ 3,000			$ 12,500
Amended Ionis
Significant agreements.
Upfront cash payment			$ 1,600
Collaboration revenues		$ 800	$ 800
Third Amended Ionis
Significant agreements.
Collaboration revenues							$ 800

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