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Significant agreements - Summary of Contract Assets and Liabilities (Details) - USD ($)
 9 Months Ended 12 Months Ended
Sep. 30, 2024
Dec. 31, 2023
Contract liabilities:    
Beginning Balance $ 135,194,000 $ 61,873,000
Additions 328,000 95,960,000
Deductions (31,567,000) (26,976,000)
Impact of Exchange Rates 5,236,000 4,337,000
Ending Balance 109,191,000 135,194,000
Contract assets    
Contract assets 0 0
Bayer collaboration deferred revenue    
Contract liabilities:    
Beginning Balance 43,618,000 0
Additions 238,000 45,000,000
Deductions (2,496,000) (1,160,000)
Impact of Exchange Rates 2,155,000 (222,000)
Ending Balance 43,515,000 43,618,000
Bayer collaboration deferred revenue | Deferred revenue material rights option    
Contract liabilities:    
Ending Balance 34,100,000  
Novartis collaboration deferred revenue    
Contract liabilities:    
Beginning Balance 50,008,000 0
Additions 0 50,000,000
Deductions (6,301,000) (1,909,000)
Impact of Exchange Rates 2,264,000 1,917,000
Ending Balance 45,971,000 50,008,000
Novartis collaboration deferred revenue | Deferred revenue material rights option    
Contract liabilities:    
Ending Balance 32,300,000  
Ionis collaboration deferred revenue    
Contract liabilities:    
Beginning Balance 12,464,000 21,489,000
Additions 90,000 960,000
Deductions (8,881,000) (10,734,000)
Impact of Exchange Rates 128,000 749,000
Ending Balance 3,801,000 12,464,000
Ionis collaboration deferred revenue | Deferred revenue material rights option    
Contract liabilities:    
Ending Balance 3,800,000  
Genentech collaboration deferred revenue    
Contract liabilities:    
Beginning Balance 29,104,000 39,308,000
Additions 0 0
Deductions (13,889,000) (11,969,000)
Impact of Exchange Rates 689,000 1,765,000
Ending Balance 15,904,000 29,104,000
Genentech collaboration deferred revenue | Deferred revenue material rights option    
Contract liabilities:    
Ending Balance 14,400,000  
AstraZeneca collaboration deferred revenue    
Contract liabilities:    
Beginning Balance $ 0 1,076,000
Additions   0
Deductions   (1,204,000)
Impact of Exchange Rates   128,000
Ending Balance   $ 0