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v3.25.0.1

Segments and geographic information - Significant segment expenses (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Segments and geographic information |  |  |
Collaboration revenue | $ 35,275 | $ 26,976 | $ 14,463
Research and development: |  |  |
Total research and development | 172,966 | 156,496 | 81,609
General and administrative: |  |  |
Effect of foreign exchange rates | 700 | 600 | 600
Total general and administrative | 72,181 | 60,426 | 49,507
Total operating expenses | 245,147 | 216,922 | 131,116
Net loss | (169,031) | (180,664) | (112,717)
Single reportable segment |  |  |
Segments and geographic information |  |  |
Collaboration revenue | 35,275 | 26,976 | 14,463
Research and development: |  |  |
Discovery, platform and other expense | 30,043 | 37,295 | 21,811
Employee and contractor related expenses | 58,687 | 46,506 | 31,346
Share-based compensation | 19,424 | 15,581 | 10,394
Facility expenses | 8,105 | 8,845 | 5,155
Research and development incentives and government grants | (43,207) | (24,459) | (20,813)
Total research and development | 172,966 | 156,496 | 81,609
General and administrative: |  |  |
Personnel-related costs | 23,500 | 18,985 | 13,948
Professional and consulting fees | 20,258 | 14,814 | 9,836
Other general and administrative costs | 9,047 | 9,137 | 8,783
Share-based compensation | 18,657 | 16,896 | 16,385
Effect of foreign exchange rates | 719 | 594 | 555
Total general and administrative | 72,181 | 60,426 | 49,507
Total operating expenses | 245,147 | 216,922 | 131,116
Other segment items | 40,841 | 9,282 | 3,936
Net loss | (169,031) | (180,664) | (112,717)
Single reportable segment | Zelenectide pevedotin (Nectin-4) |  |  |
Research and development: |  |  |
Project specific costs | 82,705 | 44,135 | 11,054
Single reportable segment | BT5528 (EphA2) |  |  |
Research and development: |  |  |
Project specific costs | 9,119 | 9,195 | 10,702
Single reportable segment | BT1718 (MT1) |  |  |
Research and development: |  |  |
Project specific costs | 250 | 520 | 692
Single reportable segment | Bicycle tumor-targeted immune cell agonists |  |  |
Research and development: |  |  |
Project specific costs | $ 7,840 | $ 18,878 | $ 11,268

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