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Commitments and contingencies - Operating Leases and Finance Leases (Details) - USD ($) $ in Thousands |  | 1 Months Ended | 12 Months Ended |  |  |  |
--- | --- | --- | --- | --- | --- | --- | ---
Dec. 06, 2021 | Jan. 31, 2023 | Dec. 31, 2023 | Dec. 31, 2024 | Dec. 31, 2022 | Dec. 31, 2021 | Sep. 30, 2017
Leases |  |  |  |  |  |  |
Operating lease right-of-use assets |  |  | $ 13,169 | $ 7,673 |  |  |
Lease liabilities |  |  |  | 9,318 |  |  |
Finance lease right-of-use assets |  |  | 0 | $ 1,000 |  |  |
Finance Lease, Right-of-Use Asset, Statement of Financial Position [Extensible Enumeration] |  |  |  | Property, Plant and Equipment, Net |  |  |
Finance lease liabilities |  |  | 0 | $ 992 |  |  |
Finance Lease, Liability, Statement of Financial Position [Extensible Enumeration] |  |  |  | Accrued Liabilities, Current, Other Liabilities, Noncurrent |  |  |
Office and laboratory space in Cambridge Massachusetts |  |  |  |  |  |  |
Leases |  |  |  |  |  |  |
Lease total contractual Term |  | 3 years |  |  |  |  |
Renewal term |  | 2 years |  |  |  |  |
Leases, term of contract |  | 3 years |  |  |  |  |
Annual rent |  | $ 2,100 |  |  |  |  |
Rental payment |  | $ 2,300 |  |  |  |  |
Rent free period |  | 2 months |  |  |  |  |
Security deposit |  | $ 500 |  |  |  |  |
Lease liabilities |  | $ 5,800 |  |  |  |  |
Discounted percentage for present value of lease payments |  | 9.00% |  |  |  |  |
New Office and laboratory space in Cambridge, United Kingdom |  |  |  |  |  |  |
Leases |  |  |  |  |  |  |
Lease total contractual Term | 10 years |  |  |  |  |  |
Renewal term | 10 years |  |  |  |  |  |
Leases, term of contract | 5 years |  |  |  |  |  |
Annual rent | $ 3,000 |  |  |  |  |  |
Rent free period | 6 months |  |  |  |  |  |
Security deposit | $ 0 |  |  |  |  |  |
Operating lease right-of-use assets | 11,600 |  |  |  |  |  |
Lease liabilities | $ 11,100 |  |  |  |  |  |
Discounted percentage for present value of lease payments | 6.90% |  |  |  |  |  |
Office and laboratory space in Building 900, Babraham Research Campus, Cambridge |  |  |  |  |  |  |
Leases |  |  |  |  |  |  |
Renewal term |  |  |  |  |  | 5 years |
Annual rent |  |  |  |  |  | $ 600 |
Estimated service charges payable |  |  |  |  |  | $ 200 |
Office and laboratory space in Building 900, Babraham Research Campus, Cambridge | General and administrative expenses |  |  |  |  |  |  |
Leases |  |  |  |  |  |  |
Loss on lease termination |  |  | 300 |  |  |  |
Office and laboratory space in Lexington, Massachusetts |  |  |  |  |  |  |
Leases |  |  |  |  |  |  |
Annual rent |  |  |  | $ 800 |  |  |
Security deposit |  |  |  |  |  |  | $ 200
Discounted percentage for present value of lease payments |  |  |  | 7.00% |  |  |
Payments for the extended lease remaining |  |  | $ 700 |  | $ 200 |  |

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