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v3.25.0.1

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Cash flows from operating activities: |  |  |
Net loss | $ (169,031) | $ (180,664) | $ (112,717)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Share-based compensation expense | 38,081 | 32,477 | 26,779
Depreciation and amortization | 7,174 | 6,546 | 3,689
Non-cash interest | 211 | 383 | 442
Loss on extinguishment of debt | 954 |  |
Gain on extinguishment of research and development funding liability | (4,476) |  |
Deferred income tax (benefit) provision | (5,226) | 3,306 | (4,976)
Other non-cash charges | 1,036 | 661 |
Changes in operating assets and liabilities: |  |  |
Accounts receivable |  | 2,482 | (1,641)
Research and development incentives receivable | (11,947) | (3,684) | (9,707)
Prepaid expenses and other assets | (2,044) | (2,072) | (2,020)
Operating lease right-of-use assets | 4,402 | 4,186 | 2,698
Accounts payable | 3,095 | 8,002 | 2,561
Accrued expenses and other current liabilities | 9,698 | 2,398 | 12,362
Operating lease liabilities | (4,888) | (4,109) | (2,114)
Deferred revenue | (31,952) | 68,951 | (2,135)
Other long-term liabilities | 189 | 509 | 668
Net cash used in operating activities | (164,724) | (60,628) | (86,111)
Cash used in investing activities: |  |  |
Purchases of property and equipment | (1,235) | (2,929) | (18,987)
Net cash used in investing activities | (1,235) | (2,929) | (18,987)
Cash flows from financing activities: |  |  |
Repayment of debt | (31,863) |  |
Proceeds from the issuance of ADSs and non-voting ordinary shares, net of issuance costs | 544,127 | 249,345 | 5,703
Proceeds from the exercise of share options and settlement of restricted share units | 7,528 | 682 | 989
Principal payments on finance lease obligations | (42) |  |
Net cash provided by financing activities | 519,750 | 250,027 | 6,692
Effect of exchange rate changes on cash, cash equivalents and restricted cash | (694) | 1,346 | (1,120)
Net increase (decrease) in cash, cash equivalents and restricted cash | 353,097 | 187,816 | (99,526)
Cash, cash equivalents and restricted cash at beginning of period | 526,970 | 339,154 | 438,680
Cash, cash equivalents and restricted cash at end of period | 880,067 | 526,970 | 339,154
Reconciliation of cash, cash equivalents and restricted cash |  |  |
Cash and cash equivalents | 879,520 | 526,423 | 339,154
Restricted cash included in other assets | 547 | 547 |
Total cash, cash equivalents and restricted cash | 880,067 | 526,970 | 339,154
Supplemental disclosure of cash flow information |  |  |
Cash paid for interest on debt | 1,373 | 2,753 | 2,793
Cash paid for interest on finance lease obligations | 23 |  |
Cash paid for income taxes | 792 | 562 | 2,228
Cash paid for amounts included in the measurement of operating lease liabilities | 5,785 | 5,595 | 3,154
Changes in purchases of property and equipment in accounts payable and accrued expenses | (4) | (1,744) | 1,564
Non-cash impact to operating lease right-of-use assets and operating lease liabilities |  | $ 3,898 | $ 3,120
Property and equipment obtained under finance leases | $ 1,102 |  |

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