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Significant agreements - Novartis Collaboration Agreement (Details) $ in Thousands |  | 12 Months Ended
--- | --- | ---
Mar. 27, 2023 USD ($) item | Dec. 31, 2024 USD ($) | Dec. 31, 2023 USD ($) | Dec. 31, 2022 USD ($)
Significant agreements. |  |  |  |
Maximum days allowed for cancellation of contracts prior written notice |  | 90 days |  |
Revenue from collaborative arrangement |  | $ 35,275 | $ 26,976 | $ 14,463
Deferred revenue |  | 101,658 | 135,194 | 61,873
Termination in entirety or product by product or target by target basis |  |  |  |
Significant agreements. |  |  |  |
Threshold period of notice required for termination of agreement | 90 days |  |  |
Completion of all milestones for targets |  |  |  |
Significant agreements. |  |  |  |
Milestone payments receivable | $ 800,000 |  |  |
Novartis |  |  |  |
Significant agreements. |  |  |  |
Number of collaboration targets | item | 2 |  |  |
Additional research term | 1 year |  |  |
Upfront cash payment | $ 50,000 |  |  |
Milestone payments receivable | 210,000 |  |  |
Milestone payments, receivable | $ 840,000 |  |  |
Maximum days allowed for cancellation of contracts prior written notice | 30 days |  |  |
Expected period for satisfaction of performance obligations | 3 years |  |  |
Material rights exercise period | 6 years |  |  |
Revenue from collaborative arrangement |  | 8,161 | 1,909 | $ 0
Deferred revenue |  | 44,073 | $ 50,008 |
Novartis | Termination based on other party's uncured material breach or insolvency |  |  |  |
Significant agreements. |  |  |  |
Threshold period of notice required for termination of agreement | 60 days |  |  |
Novartis | Termination if safety or regulatory issue exists |  |  |  |
Significant agreements. |  |  |  |
Threshold period of notice required for termination of agreement | 30 days |  |  |
Novartis | Expiration of two material rights associated with limited substitution rights |  |  |  |
Significant agreements. |  |  |  |
Revenue from collaborative arrangement |  | $ 2,500 |  |
Novartis | Achievement of specified levels of net sales |  |  |  |
Significant agreements. |  |  |  |
Milestone payments receivable | $ 200,000 |  |  |

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