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Net loss per share | 12 Months Ended
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Dec. 31, 2024
Net loss per share |
Net loss per share | 12. Net loss per share Basic and diluted net loss per share was calculated as follows (in thousands, except share and per share amounts):
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Year Ended
​ | ​ | December 31,
​ |  | 2024 |  | 2023 |  | 2022
Numerator: | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Net loss | ​ | $ | (169,031) | ​ | $ | (180,664) | ​ | $ | (112,717)
Denominator: | ​ |  |  | ​ |  |  | ​ |  |
Weighted average ordinary shares outstanding, basic and diluted | ​ |  | 58,207,593 | ​ |  | 35,592,362 | ​ |  | 29,660,659
Net loss per share, basic and diluted | ​ | $ | (2.90) | ​ | $ | (5.08) | ​ | $ | (3.80)
​ The Company’s potentially dilutive securities, which include options to purchase ordinary shares and restricted share units for ordinary shares, have been excluded from the computation of diluted net loss per share as the effect would be to reduce the net loss per share. Therefore, the weighted average number of ordinary shares outstanding, which includes both ordinary shares and non-voting ordinary shares, used to calculate both basic and diluted net loss per share is the same. The Company excluded the following potentially dilutive ordinary shares, presented based on amounts outstanding at each period end, from the computation of diluted net loss per share for the periods indicated because including them would have had an anti-dilutive effect: ​
​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | December 31,
​ |  | 2024 |  | 2023 |  | 2022
Restricted ordinary shares |  | 716,262 |  | 326,848 |  | 187,725
Options to purchase ordinary shares |  | 8,748,726 |  | 7,469,527 |  | 5,898,888
​ |  | 9,464,988 |  | 7,796,375 |  | 6,086,613
​

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