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Ordinary shares - Share Purchase Agreement (Details) $ / shares in Units, $ in Thousands |  |  | 12 Months Ended |  |  |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | ---
May 28, 2024 USD ($) | Jul. 17, 2023 USD ($) shares | Dec. 31, 2024 USD ($) shares | Dec. 31, 2023 USD ($) shares | Dec. 31, 2022 USD ($) shares | Dec. 31, 2024 £ / shares shares | May 23, 2024 £ / shares shares | May 23, 2024 $ / shares shares | Dec. 31, 2023 £ / shares shares | Jul. 17, 2023 £ / shares | Jul. 17, 2023 $ / shares | Dec. 31, 2021 shares
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Ordinary shares, shares issued |  |  |  |  |  | 69,061,418 |  |  | 42,431,766 |  |  |
Ordinary shares, shares outstanding |  |  |  |  |  | 69,061,418 |  |  | 42,431,766 |  |  |
Ordinary shares, nominal value | £ / shares |  |  |  |  |  | £ 0.01 |  |  | £ 0.01 |  |  |
Gross proceeds before discounts and commissions | $ |  |  | $ 544,127 | $ 249,345 | $ 5,703 |  |  |  |  |  |  |
Commissions and offering expenses | $ |  |  | 11,400 | 16,000 | 200 |  |  |  |  |  |  |
Proceeds from the issuance, net of issuance costs | $ |  |  | 544,127 | 249,345 | $ 5,703 |  |  |  |  |  |  |
Ordinary Shares |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Ordinary shares, shares outstanding |  |  |  |  | 29,873,893 | 69,061,418 |  |  | 42,431,766 |  |  | 29,579,364
Gross proceeds before discounts and commissions | $ |  |  | $ 331 | $ 162 | $ 2 |  |  |  |  |  |  |
Shares issued (in shares) |  |  | 25,933,706 | 12,384,706 | 181,455 |  |  |  |  |  |  |
Non voting ordinary shares | Ordinary Shares |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Ordinary shares, shares issued |  |  |  |  |  | 21,492,099 |  |  |  |  |  |
Ordinary shares, shares outstanding |  |  |  |  |  | 21,492,099 |  |  |  |  |  |
Voting ordinary shares | Ordinary Shares |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Ordinary shares, shares issued |  |  |  |  |  | 47,569,319 |  |  |  |  |  |
Ordinary shares, shares outstanding |  |  |  |  |  | 47,569,319 |  |  |  |  |  |
At the market offering |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Gross proceeds before discounts and commissions | $ |  |  |  | $ 35,300 | $ 5,900 |  |  |  |  |  |  |
Commissions and offering expenses | $ |  |  |  | 1,100 | 200 |  |  |  |  |  |  |
Proceeds from the issuance, net of issuance costs | $ |  |  |  | $ 34,200 | $ 5,700 |  |  |  |  |  |  |
Shares issued (in shares) |  |  | 0 |  |  |  |  |  |  |  |  |
At the market offering | American Depositary Shares |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Shares issued (in shares) |  |  |  | 1,561,176 | 181,455 |  |  |  |  |  |  |
Underwritten Public Offering |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Gross proceeds before discounts and commissions | $ |  | $ 230,000 |  |  |  |  |  |  |  |  |  |
Commissions and offering expenses | $ |  | 14,900 |  |  |  |  |  |  |  |  |  |
Proceeds from the issuance, net of issuance costs | $ |  | $ 215,100 |  |  |  |  |  |  |  |  |  |
Underwritten Public Offering | American Depositary Shares |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Ordinary shares, nominal value | £ / shares |  |  |  |  |  |  |  |  |  | £ 0.01 |  |
Shares issued (in shares) |  | 6,117,648 |  |  |  |  |  |  |  |  |  |
Price per share | $ / shares |  |  |  |  |  |  |  |  |  |  | $ 21.25 |
Underwritten Public Offering | American Depositary Shares | Option on securities |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Shares issued (in shares) |  | 1,411,764 |  |  |  |  |  |  |  |  |  |
Underwritten Public Offering | Non voting ordinary shares |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Ordinary shares, nominal value | £ / shares |  |  |  |  |  |  |  |  |  | £ 0.01 |  |
Shares issued (in shares) |  | 4,705,882 |  |  |  |  |  |  |  |  |  |
Investors Purchase Agreement |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Gross proceeds before discounts and commissions | $ | $ 555,500 |  |  |  |  |  |  |  |  |  |  |
Commissions and offering expenses | $ | 11,400 |  |  |  |  |  |  |  |  |  |  |
Proceeds from the issuance, net of issuance costs | $ | $ 544,100 |  |  |  |  |  |  |  |  |  |  |
Price per share | $ / shares |  |  |  |  |  |  |  | $ 21.42 |  |  |  |
Investors Purchase Agreement | American Depositary Shares |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Ordinary shares, shares issued |  |  |  |  |  |  | 6,764,705 | 6,764,705 |  |  |  |
Ordinary shares, nominal value | £ / shares |  |  |  |  |  |  | £ 0.01 |  |  |  |  |
Investors Purchase Agreement | Non voting ordinary shares |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Ordinary shares, shares issued |  |  |  |  |  |  | 19,169,001 | 19,169,001 |  |  |  |
Ordinary shares, nominal value | £ / shares |  |  |  |  |  |  | £ 0.01 |  |  |  |  |

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