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Ordinary shares - Share Purchase Agreement (Details)
$ / shares in Units, $ in Thousands
 12 Months Ended
May 28, 2024
USD ($)
Jul. 17, 2023
USD ($)
shares
Dec. 31, 2024
USD ($)
shares
Dec. 31, 2023
USD ($)
shares
Dec. 31, 2022
USD ($)
shares
Dec. 31, 2024
£ / shares
shares
May 23, 2024
£ / shares
shares
May 23, 2024
$ / shares
shares
Dec. 31, 2023
£ / shares
shares
Jul. 17, 2023
£ / shares
Jul. 17, 2023
$ / shares
Dec. 31, 2021
shares
Class of Stock [Line Items]                        
Ordinary shares, shares issued           69,061,418     42,431,766      
Ordinary shares, shares outstanding           69,061,418     42,431,766      
Ordinary shares, nominal value | £ / shares           £ 0.01     £ 0.01      
Gross proceeds before discounts and commissions | $     $ 544,127 $ 249,345 $ 5,703              
Commissions and offering expenses | $     11,400 16,000 200              
Proceeds from the issuance, net of issuance costs | $     544,127 249,345 $ 5,703              
Ordinary Shares                        
Class of Stock [Line Items]                        
Ordinary shares, shares outstanding         29,873,893 69,061,418     42,431,766     29,579,364
Gross proceeds before discounts and commissions | $     $ 331 $ 162 $ 2              
Shares issued (in shares)     25,933,706 12,384,706 181,455              
Non voting ordinary shares | Ordinary Shares                        
Class of Stock [Line Items]                        
Ordinary shares, shares issued           21,492,099            
Ordinary shares, shares outstanding           21,492,099            
Voting ordinary shares | Ordinary Shares                        
Class of Stock [Line Items]                        
Ordinary shares, shares issued           47,569,319            
Ordinary shares, shares outstanding           47,569,319            
At the market offering                        
Class of Stock [Line Items]                        
Gross proceeds before discounts and commissions | $       $ 35,300 $ 5,900              
Commissions and offering expenses | $       1,100 200              
Proceeds from the issuance, net of issuance costs | $       $ 34,200 $ 5,700              
Shares issued (in shares)     0                  
At the market offering | American Depositary Shares                        
Class of Stock [Line Items]                        
Shares issued (in shares)       1,561,176 181,455              
Underwritten Public Offering                        
Class of Stock [Line Items]                        
Gross proceeds before discounts and commissions | $   $ 230,000                    
Commissions and offering expenses | $   14,900                    
Proceeds from the issuance, net of issuance costs | $   $ 215,100                    
Underwritten Public Offering | American Depositary Shares                        
Class of Stock [Line Items]                        
Ordinary shares, nominal value | £ / shares                   £ 0.01    
Shares issued (in shares)   6,117,648                    
Price per share | $ / shares                     $ 21.25  
Underwritten Public Offering | American Depositary Shares | Option on securities                        
Class of Stock [Line Items]                        
Shares issued (in shares)   1,411,764                    
Underwritten Public Offering | Non voting ordinary shares                        
Class of Stock [Line Items]                        
Ordinary shares, nominal value | £ / shares                   £ 0.01    
Shares issued (in shares)   4,705,882                    
Investors Purchase Agreement                        
Class of Stock [Line Items]                        
Gross proceeds before discounts and commissions | $ $ 555,500                      
Commissions and offering expenses | $ 11,400                      
Proceeds from the issuance, net of issuance costs | $ $ 544,100                      
Price per share | $ / shares               $ 21.42        
Investors Purchase Agreement | American Depositary Shares                        
Class of Stock [Line Items]                        
Ordinary shares, shares issued             6,764,705 6,764,705        
Ordinary shares, nominal value | £ / shares             £ 0.01          
Investors Purchase Agreement | Non voting ordinary shares                        
Class of Stock [Line Items]                        
Ordinary shares, shares issued             19,169,001 19,169,001        
Ordinary shares, nominal value | £ / shares             £ 0.01