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Significant agreements - Collaboration revenues (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Significant agreements.
Collaboration revenue	$ 35,275	$ 26,976	$ 14,463
Bayer
Significant agreements.
Collaboration revenue	3,393	1,160	0
Novartis
Significant agreements.
Collaboration revenue	8,161	1,909	0
Ionis
Significant agreements.
Collaboration revenue	8,881	10,734	9,347
Genentech
Significant agreements.
Collaboration revenue	$ 14,840	11,969	3,565
Dementia Discovery Fund
Significant agreements.
Collaboration revenue			386
AstraZeneca
Significant agreements.
Collaboration revenue		$ 1,204	$ 1,165

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