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Significant agreements - Ionis Collaboration Agreement (Details)
$ in Millions
1 Months Ended
Jul. 09, 2021
USD ($)
item
Apr. 30, 2023
USD ($)
Dec. 31, 2021
USD ($)
Ionis      
Significant agreements.      
Period for which research and discovery activities will be performed with no additional consideration 3 years    
Upfront cash payment $ 31.0    
Number of payments of a mid-single-digit million dollar, failing to achieve the specified development diligence | item 3    
Number of collaboration targets | item 4    
Number of years over which royalty is payable 10 years    
Amended Ionis      
Significant agreements.      
Upfront cash payment     $ 1.6
Third Ionis Amendment      
Significant agreements.      
Upfront cash payment   $ 0.8