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Significant agreements - Ionis Share Purchase Agreement (Details) - USD ($) $ / shares in Units, $ in Thousands		12 Months Ended
	Jul. 09, 2021	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022	Sep. 07, 2021
Significant agreements.
Aggregate purchase price		$ 544,127	$ 249,345	$ 5,703
Ionis
Significant agreements.
Transaction price	$ 38,000	$ 37,800			$ 38,000
Ionis | Ionis Share Purchase Agreement
Significant agreements.
Shares issued (in shares)	282,485
Purchase price per share	$ 38.94
Aggregate purchase price	$ 11,000
Fair value of shares held	7,600
Transaction price	$ 3,400
Ionis | Ionis Share Purchase Agreement | American Depositary Shares
Significant agreements.
Purchase price per share	$ 31.11

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