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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Cash flows from operating activities:      
Net loss $ (169,031) $ (180,664) $ (112,717)
Adjustments to reconcile net loss to net cash used in operating activities:      
Share-based compensation expense 38,081 32,477 26,779
Depreciation and amortization 7,174 6,546 3,689
Non-cash interest 211 383 442
Loss on extinguishment of debt 954    
Gain on extinguishment of research and development funding liability (4,476)    
Deferred income tax (benefit) provision (5,226) 3,306 (4,976)
Other non-cash charges 1,036 661  
Changes in operating assets and liabilities:      
Accounts receivable   2,482 (1,641)
Research and development incentives receivable (11,947) (3,684) (9,707)
Prepaid expenses and other assets (2,044) (2,072) (2,020)
Operating lease right-of-use assets 4,402 4,186 2,698
Accounts payable 3,095 8,002 2,561
Accrued expenses and other current liabilities 9,698 2,398 12,362
Operating lease liabilities (4,888) (4,109) (2,114)
Deferred revenue (31,952) 68,951 (2,135)
Other long-term liabilities 189 509 668
Net cash used in operating activities (164,724) (60,628) (86,111)
Cash used in investing activities:      
Purchases of property and equipment (1,235) (2,929) (18,987)
Net cash used in investing activities (1,235) (2,929) (18,987)
Cash flows from financing activities:      
Repayment of debt (31,863)    
Proceeds from the issuance of ADSs and non-voting ordinary shares, net of issuance costs 544,127 249,345 5,703
Proceeds from the exercise of share options and settlement of restricted share units 7,528 682 989
Principal payments on finance lease obligations (42)    
Net cash provided by financing activities 519,750 250,027 6,692
Effect of exchange rate changes on cash, cash equivalents and restricted cash (694) 1,346 (1,120)
Net increase (decrease) in cash, cash equivalents and restricted cash 353,097 187,816 (99,526)
Cash, cash equivalents and restricted cash at beginning of period 526,970 339,154 438,680
Cash, cash equivalents and restricted cash at end of period 880,067 526,970 339,154
Reconciliation of cash, cash equivalents and restricted cash      
Cash and cash equivalents 879,520 526,423 339,154
Restricted cash included in other assets 547 547  
Total cash, cash equivalents and restricted cash 880,067 526,970 339,154
Supplemental disclosure of cash flow information      
Cash paid for interest on debt 1,373 2,753 2,793
Cash paid for interest on finance lease obligations 23    
Cash paid for income taxes 792 562 2,228
Cash paid for amounts included in the measurement of operating lease liabilities 5,785 5,595 3,154
Changes in purchases of property and equipment in accounts payable and accrued expenses (4) (1,744) 1,564
Non-cash impact to operating lease right-of-use assets and operating lease liabilities   $ 3,898 $ 3,120
Property and equipment obtained under finance leases $ 1,102