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Commitments and contingencies - Operating Leases and Finance Leases (Details) - USD ($) $ in Thousands		1 Months Ended	12 Months Ended
	Dec. 06, 2021	Jan. 31, 2023	Dec. 31, 2023	Dec. 31, 2024	Dec. 31, 2022	Dec. 31, 2021	Sep. 30, 2017
Leases
Operating lease right-of-use assets			$ 13,169	$ 7,673
Lease liabilities				9,318
Finance lease right-of-use assets			0	$ 1,000
Finance Lease, Right-of-Use Asset, Statement of Financial Position [Extensible Enumeration]				Property, Plant and Equipment, Net
Finance lease liabilities			0	$ 992
Finance Lease, Liability, Statement of Financial Position [Extensible Enumeration]				Accrued Liabilities, Current, Other Liabilities, Noncurrent
Office and laboratory space in Cambridge Massachusetts
Leases
Lease total contractual Term		3 years
Renewal term		2 years
Leases, term of contract		3 years
Annual rent		$ 2,100
Rental payment		$ 2,300
Rent free period		2 months
Security deposit		$ 500
Lease liabilities		$ 5,800
Discounted percentage for present value of lease payments		9.00%
New Office and laboratory space in Cambridge, United Kingdom
Leases
Lease total contractual Term	10 years
Renewal term	10 years
Leases, term of contract	5 years
Annual rent	$ 3,000
Rent free period	6 months
Security deposit	$ 0
Operating lease right-of-use assets	11,600
Lease liabilities	$ 11,100
Discounted percentage for present value of lease payments	6.90%
Office and laboratory space in Building 900, Babraham Research Campus, Cambridge
Leases
Renewal term						5 years
Annual rent						$ 600
Estimated service charges payable						$ 200
Office and laboratory space in Building 900, Babraham Research Campus, Cambridge | General and administrative expenses
Leases
Loss on lease termination			300
Office and laboratory space in Lexington, Massachusetts
Leases
Annual rent				$ 800
Security deposit							$ 200
Discounted percentage for present value of lease payments				7.00%
Payments for the extended lease remaining			$ 700		$ 200

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Total contractual term of lessee's operating lease, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

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