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Segments and geographic information - Significant segment expenses (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Segments and geographic information      
Collaboration revenue $ 35,275 $ 26,976 $ 14,463
Research and development:      
Total research and development 172,966 156,496 81,609
General and administrative:      
Effect of foreign exchange rates 700 600 600
Total general and administrative 72,181 60,426 49,507
Total operating expenses 245,147 216,922 131,116
Net loss (169,031) (180,664) (112,717)
Single reportable segment      
Segments and geographic information      
Collaboration revenue 35,275 26,976 14,463
Research and development:      
Discovery, platform and other expense 30,043 37,295 21,811
Employee and contractor related expenses 58,687 46,506 31,346
Share-based compensation 19,424 15,581 10,394
Facility expenses 8,105 8,845 5,155
Research and development incentives and government grants (43,207) (24,459) (20,813)
Total research and development 172,966 156,496 81,609
General and administrative:      
Personnel-related costs 23,500 18,985 13,948
Professional and consulting fees 20,258 14,814 9,836
Other general and administrative costs 9,047 9,137 8,783
Share-based compensation 18,657 16,896 16,385
Effect of foreign exchange rates 719 594 555
Total general and administrative 72,181 60,426 49,507
Total operating expenses 245,147 216,922 131,116
Other segment items 40,841 9,282 3,936
Net loss (169,031) (180,664) (112,717)
Single reportable segment | Zelenectide pevedotin (Nectin-4)      
Research and development:      
Project specific costs 82,705 44,135 11,054
Single reportable segment | BT5528 (EphA2)      
Research and development:      
Project specific costs 9,119 9,195 10,702
Single reportable segment | BT1718 (MT1)      
Research and development:      
Project specific costs 250 520 692
Single reportable segment | Bicycle tumor-targeted immune cell agonists      
Research and development:      
Project specific costs $ 7,840 $ 18,878 $ 11,268