<SEC-DOCUMENT>0001972481-25-000229.txt : 20251002
<SEC-HEADER>0001972481-25-000229.hdr.sgml : 20251002
<ACCEPTANCE-DATETIME>20251002172150
ACCESSION NUMBER:		0001972481-25-000229
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20251002
DATE AS OF CHANGE:		20251002

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BICYCLE THERAPEUTICS PLC
		CENTRAL INDEX KEY:			0001761612
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				000000000
		STATE OF INCORPORATION:			X0
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-38916
		FILM NUMBER:		251370732

	BUSINESS ADDRESS:	
		STREET 1:		BLOCKS A & B, PORTWAY BUILDING
		STREET 2:		GRANTA PARK, GREAT ABINGTON
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB21 6GS
		BUSINESS PHONE:		011441223261503

	MAIL ADDRESS:	
		STREET 1:		BLOCKS A & B, PORTWAY BUILDING
		STREET 2:		GRANTA PARK, GREAT ABINGTON
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB21 6GS

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	BICYCLE THERAPEUTICS plc
		DATE OF NAME CHANGE:	20190530

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	BICYCLE THERAPEUTICS Ltd
		DATE OF NAME CHANGE:	20181212

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Thompson Travis Alvin
		CENTRAL INDEX KEY:			0001983944
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		C/O BICYCLE THERAPEUTICS PLC
		STREET 2:		BLOCKS A & B, PORTWAY BUILDING
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB21 6GS
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001983944</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001761612</issuerCik>
      <issuerName>BICYCLE THERAPEUTICS PLC</issuerName>
      <secFileNumber>001-38916</secFileNumber>
      <issuerAddress>
        <com:street1>BLOCKS A &amp; B, PORTWAY BUILDING</com:street1>
        <com:street2>GRANTA PARK, GREAT ABINGTON</com:street2>
        <com:city>CAMBRIDGE</com:city>
        <com:stateOrCountry>X0</com:stateOrCountry>
        <com:zipCode>CB21 6GS</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>011441223261503</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Thompson Travis Alvin</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Stifel Nicolaus &amp; Company Inc</name>
        <address>
          <com:street1>501 N Broadway</com:street1>
          <com:city>St. Louis</com:city>
          <com:stateOrCountry>MO</com:stateOrCountry>
          <com:zipCode>63102</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>543</noOfUnitsSold>
      <aggregateMarketValue>4563.00</aggregateMarketValue>
      <noOfUnitsOutstanding>49868567</noOfUnitsOutstanding>
      <approxSaleDate>10/02/2025</approxSaleDate>
      <securitiesExchangeName> Nasdaq </securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>10/02/2025</acquiredDate>
      <natureOfAcquisitionTransaction> Restricted Stock Units </natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1000</amountOfSecuritiesAcquired>
      <paymentDate>10/02/2025</paymentDate>
      <natureOfPayment>Equity Compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>10/03/2025</acquiredDate>
      <natureOfAcquisitionTransaction> Restricted Stock Units </natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired> Issuer </nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>593</amountOfSecuritiesAcquired>
      <paymentDate>10/03/2025</paymentDate>
      <natureOfPayment> Equity Compensation </natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Travis Thompson</name>
        <address>
          <com:street1> Blocks A &amp; B Portway Building </com:street1>
          <com:city> Cambridge </com:city>
          <com:stateOrCountry>X0</com:stateOrCountry>
          <com:zipCode> CB21 6GS </com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle> Common Stock </securitiesClassTitle>
      <saleDate>07/02/2025</saleDate>
      <amountOfSecuritiesSold>204</amountOfSecuritiesSold>
      <grossProceeds>1447.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Travis Thompson</name>
        <address>
          <com:street1>Blocks A &amp; B Portway Building</com:street1>
          <com:city>Cambridge</com:city>
          <com:stateOrCountry>X0</com:stateOrCountry>
          <com:zipCode>CB21 6GS</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle> Common Stock </securitiesClassTitle>
      <saleDate>07/03/2025</saleDate>
      <amountOfSecuritiesSold>100</amountOfSecuritiesSold>
      <grossProceeds>744.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>10/02/2025</noticeDate>
      <signature>/s/ James Weimer, as a duly authorized representative of STIFEL, as attorney-in-fact for Travis Thompson</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
