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Net Income (Loss) Per Ordinary Share
 9 Months Ended
Sep. 30, 2025
Earnings Per Share [Abstract]  
Net Income (Loss) Per Ordinary Share Net Loss Per Ordinary Share
Net loss per ordinary share was determined as follows (in thousands, except per share amounts):
Three Months Ended 
September 30,		Nine Months Ended 
September 30,
2025202420252024
Numerator:
Net loss
$(36,541)$(59,001)$(222,503)$(64,354)
Denominator:
Weighted-average ordinary shares outstanding used in per share calculations53,830 53,790 53,828 53,757 
Net loss per share:
Basic and diluted net loss per ordinary share
$(0.68)$(1.10)$(4.13)$(1.20)
Potentially issuable ordinary shares were not used in computing diluted net loss per ordinary share as their effect would be anti-dilutive due to the loss recorded during the three and nine months ended September 30, 2025 and 2024, and therefore diluted net loss per share is equal to basic net loss per share.
The equivalent ordinary shares not included in diluted net income (loss) per share because their effect would be anti-dilutive are as follows (in thousands):
 Three Months Ended 
September 30,		Nine Months Ended 
September 30,
2025202420252024
Stock options to purchase ordinary shares11,627 11,297 11,627 11,297 
Restricted Stock Units (RSU)1,133 24 1,133 24 
Total12,760 11,321 12,760 11,321