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Net Income (Loss) Per Ordinary Share (Tables)
9 Months Ended
Sep. 30, 2025
Earnings Per Share [Abstract]  
Calculation of Basic and Diluted Net Income (Loss) Per Ordinary Share
Net loss per ordinary share was determined as follows (in thousands, except per share amounts):
Three Months Ended 
September 30,
Nine Months Ended 
September 30,
2025202420252024
Numerator:
Net loss
$(36,541)$(59,001)$(222,503)$(64,354)
Denominator:
Weighted-average ordinary shares outstanding used in per share calculations53,830 53,790 53,828 53,757 
Net loss per share:
Basic and diluted net loss per ordinary share
$(0.68)$(1.10)$(4.13)$(1.20)
Ordinary Shares Equivalent Not Included in Diluted Net Income (Loss) Per Ordinary Share
The equivalent ordinary shares not included in diluted net income (loss) per share because their effect would be anti-dilutive are as follows (in thousands):
 Three Months Ended 
September 30,
Nine Months Ended 
September 30,
2025202420252024
Stock options to purchase ordinary shares11,627 11,297 11,627 11,297 
Restricted Stock Units (RSU)1,133 24 1,133 24 
Total12,760 11,321 12,760 11,321