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Condensed Consolidated Statements of Operations - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2025
Sep. 30, 2024
Sep. 30, 2025
Sep. 30, 2024
Total revenue $ 2,415 $ 970 $ 9,663 $ 133,034
Operating expenses:        
Research and development 28,938 50,723 120,266 172,347
General and administrative 13,238 16,760 46,746 50,351
Restructuring costs 479 0 33,088 0
Total operating expenses 42,655 67,483 200,100 222,698
Loss from operations (40,240) (66,513) (190,437) (89,664)
Other income (expense):        
Interest income 3,351 6,743 11,493 20,429
Other expense, net (23) (66) (306) (194)
Total other income, net 3,328 6,677 11,187 20,235
Loss before income taxes (36,912) (59,836) (179,250) (69,429)
Provision for (benefit from) income taxes (371) (835) 43,253 (5,075)
Net Income (Loss) $ (36,541) $ (59,001) $ (222,503) $ (64,354)
Basic (in dollars per share) $ (0.68) $ (1.10) $ (4.13) $ (1.20)
Diluted (in dollars per share) $ (0.68) $ (1.10) $ (4.13) $ (1.20)
Weighted-average ordinary shares outstanding used in per share calculations- basic (in shares) 53,830 53,790 53,828 53,757
Weighted-average ordinary shares outstanding used in per share calculations- diluted (in shares) 53,830 53,790 53,828 53,757
Collaboration revenue        
Total revenue $ 2,415 $ 970 $ 9,613 $ 132,984
Revenue from license and intellectual property        
Total revenue $ 0 $ 0 $ 50 $ 50