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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2025
Sep. 30, 2024
Sep. 30, 2025
Sep. 30, 2024
Operating activities        
Net loss $ (36,541) $ (59,001) $ (222,503) $ (64,354)
Adjustments to reconcile net loss to cash used in operating activities:        
Depreciation     677 672
Share-based compensation 7,199 11,020 30,566 35,444
Deferred income taxes     43,239 (7,109)
Reduction in the carrying amount of right-of-use assets     2,083 2,000
Loss on disposal of fixed assets     3 0
Changes in operating assets and liabilities:        
Accounts receivable     0 5,159
Prepaid and other assets     9,178 768
Accounts payable, accruals and other liabilities     (9,527) (20,289)
Deferred revenue     (9,613) (52,984)
Restructuring liability     17,614 0
Operating lease liabilities     (1,985) (1,585)
Net cash used in operating activities     (140,268) (102,278)
Investing activities        
Purchases of property and equipment     (138) (255)
Net cash used in investing activities     (138) (255)
Financing activities        
Proceeds from issuance of ordinary shares upon exercise of stock options     0 1,908
Net cash provided by (used in) financing activities     (139) 1,613
Net decrease in cash, cash equivalents and restricted cash     (140,545) (100,920)
Cash, cash equivalents and restricted cash, beginning of the year     472,248 621,042
Cash, cash equivalents and restricted cash, end of the period 331,703 520,122 331,703 520,122
Supplemental disclosures of cash flow information        
Cash paid for income taxes     941 2,412
Supplemental disclosures of non-cash investing and financing activities        
Acquisition of property and equipment included in accounts payable and accrued liabilities     0 71
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability     224 217
Cash and cash equivalents 330,843 519,262 330,843 519,262
Restricted cash, non-current 860 860 860 860
Total cash, cash equivalents and restricted cash, end of the period $ 331,703 $ 520,122 331,703 520,122
At-The-Market Offering        
Financing activities        
Proceeds from issuance of ordinary shares in at-the-market offering, net     $ (139) $ (295)