<SEC-DOCUMENT>0001045463-25-000006.txt : 20250514
<SEC-HEADER>0001045463-25-000006.hdr.sgml : 20250514
<ACCEPTANCE-DATETIME>20250514103449
ACCESSION NUMBER:		0001045463-25-000006
CONFORMED SUBMISSION TYPE:	SCHEDULE 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20250514
DATE AS OF CHANGE:		20250514

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PROTHENA CORP PUBLIC LTD CO
		CENTRAL INDEX KEY:			0001559053
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				000000000
		STATE OF INCORPORATION:			L2
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-87112
		FILM NUMBER:		25943324

	BUSINESS ADDRESS:	
		STREET 1:		77 SIR JOHN ROGERSON'S QUAY, BLOCK C
		STREET 2:		GRAND CANAL DOCKLANDS
		CITY:			DUBLIN 2
		STATE:			L2
		ZIP:			D02 VK60
		BUSINESS PHONE:		011-353-1-236-2500

	MAIL ADDRESS:	
		STREET 1:		77 SIR JOHN ROGERSON'S QUAY, BLOCK C
		STREET 2:		GRAND CANAL DOCKLANDS
		CITY:			DUBLIN 2
		STATE:			L2
		ZIP:			D02 VK60

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Prothena Corp plc
		DATE OF NAME CHANGE:	20121102

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Neotope Corp Ltd
		DATE OF NAME CHANGE:	20120926

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SCULLY WILLIAM P
		CENTRAL INDEX KEY:			0001045463
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A

	MAIL ADDRESS:	
		STREET 1:		C/O MCGRATH DOYLE & PHAIR
		STREET 2:		150 BROADWAY
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10038
</SEC-HEADER>
<DOCUMENT>
<TYPE>SCHEDULE 13G/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>SCHEDULE 13G/A</submissionType>
    <previousAccessionNumber>0001193125-24-035471</previousAccessionNumber>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001045463</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <amendmentNo>3</amendmentNo>
      <securitiesClassTitle>Ordinary Shares, $0.01 par value</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>03/31/2025</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001559053</issuerCik>
        <issuerName>PROTHENA CORP PUBLIC LTD CO</issuerName>
        <issuerCusip>G72800108</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>77 SIR JOHN ROGERSON'S QUAY, BLOCK C</com:street1>
          <com:street2>77 SIR JOHN ROGERSON'S QUAY, BLOCK C</com:street2>
          <com:city>DUBLIN 2</com:city>
          <com:stateOrCountry>L2</com:stateOrCountry>
          <com:zipCode>D02 VK60</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(c)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>SCULLY WILLIAM P</reportingPersonName>
      <citizenshipOrOrganization>FL</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>793943.00</soleVotingPower>
        <sharedVotingPower>4813805.00</sharedVotingPower>
        <soleDispositivePower>793943.00</soleDispositivePower>
        <sharedDispositivePower>4813805.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>5607748.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <classPercent>10.4</classPercent>
      <typeOfReportingPerson>IN</typeOfReportingPerson>
      <comments>See Item 4 as to disclaimer of beneficial ownership.</comments>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>PROTHENA CORP PUBLIC LTD CO</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>77 SIR JOHN ROGERSON'S QUAY, BLOCK C, 77 SIR JOHN ROGERSON'S QUAY, BLOCK C, DUBLIN 2, IRELAND, D02 VK60.</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>William P. Scully</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>771 Manatee Cove, Vero Beach, Florida 32963</principalBusinessOfficeOrResidenceAddress>
        <citizenship>Florida</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>Y</notApplicableFlag>
      </item3>
      <item4>
        <amountBeneficiallyOwned>The Reporting Person may be deemed to be the beneficial owner of 5,607,748 Ordinary Shares.  This amount consists of (i) 34,993 Ordinary Shares owned directly by the Reporting Person over which he has sole voting and dispositive power, (ii) 75,950 Ordinary Shares owned by Manatee Equity Fund LLC, of which the Reporting Person is the sole manager with sole voting and dispositive power, (iii) 683,000 Ordinary Shares owned by the Reporting Persons IRA, over which he has sole voting and dispositive power, (iv) 42,000 Ordinary Shares owned by the Reporting Persons spouses IRA, over which he may be deemed to have shared voting and dispositive power, (v) 5,000 Ordinary Shares owned by the Reporting Persons spouse, over which he may be deemed to have shared voting and dispositive power (vi) 18,000 Ordinary Shares owned by an IRA subject to an investment management agreement over which the Reporting Person may be deemed to have shared voting and dispositive power by reason of his right to terminate such agreement, (vii) 158,000 Ordinary Shares owned in the aggregate by various trusts, of which the Reporting Person may be deemed to have shared voting and dispositive power by virtue of being a co-trustee, (viii) 4,098,346 Ordinary Shares owned in the aggregate by various grantor retained annuity trusts, which have an independent trustee, but over which the Reporting Person may be deemed to have shared voting and dispositive power by reason of his retained right to substitute assets in such trusts, and (ix) 492,459 Ordinary Shares owned in the aggregate by various other trusts, which have an independent trustee, but over which the Reporting Person may be deemed to have shared voting and dispositive power by reason of his retained right to substitute assets in such trusts.</amountBeneficiallyOwned>
        <classPercent>According to the Issuers most recent Annual Report on Form 10-K for the year ended December 31, 2024, the number of shares outstanding as of February 20, 2025 was 53,826,982.  The Ordinary Shares which the Reporting Person may be deemed to beneficially own constitute approximately 10.42 percent of such total number of shares.</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>793,943</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>4,813,805</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>793,943</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>4,813,805</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under &amp;#167; 240.14a-11.

</certifications>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>SCULLY WILLIAM P</reportingPersonName>
      <signatureDetails>
        <signature>Diana L. Hayes</signature>
        <title>By POA from William P. Scully</title>
        <date>05/14/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureComments>Pursuant to a Limited Power of Attorney dated as of February 13, 2024, a copy of which is on file with the Commission.</signatureComments>
  </formData>
</edgarSubmission>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
