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<!--XBRL Document Modified with Ez-Viewer on Friday, March 09, 2012 06:41:37 AM Document Version 1.1-->
<!--XBRL Document Modified with Ez-Viewer on Friday, March 09, 2012 12:43:26 AM Document Version 1.0-->
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			<link:roleType roleURI="http://www.cassinfo.com/role/DocumentAndEntityInformation" id="DocumentAndEntityInformation">
				<link:definition>001 - Document - Document And Entity Information</link:definition>
				<link:usedOn>link:presentationLink</link:usedOn>
				<link:usedOn>link:definitionLink</link:usedOn>
				<link:usedOn>link:calculationLink</link:usedOn>
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			<link:roleType roleURI="http://www.cassinfo.com/role/StatementOfFinancialPositionUnclassified-DepositBasedOperations" id="StatementOfFinancialPositionUnclassified-DepositBasedOperations">
				<link:definition>002 - Statement - CONSOLIDATED BALANCE SHEETS</link:definition>
				<link:usedOn>link:presentationLink</link:usedOn>
				<link:usedOn>link:definitionLink</link:usedOn>
				<link:usedOn>link:calculationLink</link:usedOn>
			</link:roleType>
			<link:roleType roleURI="http://www.cassinfo.com/role/Balancesheetsparenthetical" id="Balancesheetsparenthetical">
				<link:definition>003 - Statement - CONSOLIDATED BALANCE SHEETS [Parenthetical]</link:definition>
				<link:usedOn>link:presentationLink</link:usedOn>
				<link:usedOn>link:definitionLink</link:usedOn>
				<link:usedOn>link:calculationLink</link:usedOn>
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			<link:roleType roleURI="http://www.cassinfo.com/role/StatementOfIncomeInterestBasedRevenue" id="StatementOfIncomeInterestBasedRevenue">
				<link:definition>004 - Statement - CONSOLIDATED STATEMENTS OF INCOME</link:definition>
				<link:usedOn>link:presentationLink</link:usedOn>
				<link:usedOn>link:definitionLink</link:usedOn>
				<link:usedOn>link:calculationLink</link:usedOn>
			</link:roleType>
			<link:roleType roleURI="http://www.cassinfo.com/role/StatementOfCashFlowsIndirectDepositBasedOperations" id="StatementOfCashFlowsIndirectDepositBasedOperations">
				<link:definition>005 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS</link:definition>
				<link:usedOn>link:presentationLink</link:usedOn>
				<link:usedOn>link:definitionLink</link:usedOn>
				<link:usedOn>link:calculationLink</link:usedOn>
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			<link:roleType roleURI="http://www.cassinfo.com/role/StatementOfShareholdersEquityAndOtherComprehensiveIncome" id="StatementOfShareholdersEquityAndOtherComprehensiveIncome">
				<link:definition>006 - Statement - CONSOLIDATED STATEMENTS OF SHAREHOLDERS' EQUITY AND COMPREHENSIVE INCOME</link:definition>
				<link:usedOn>link:presentationLink</link:usedOn>
				<link:usedOn>link:definitionLink</link:usedOn>
				<link:usedOn>link:calculationLink</link:usedOn>
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			<link:roleType roleURI="http://www.cassinfo.com/role/SharehlodersEquityParanthetical" id="SharehlodersEquityParanthetical">
				<link:definition>007 - Statement - CONSOLIDATED STATEMENTS OF SHAREHOLDERS' EQUITY AND COMPREHENSIVE INCOME [Paranthetical]</link:definition>
				<link:usedOn>link:presentationLink</link:usedOn>
				<link:usedOn>link:definitionLink</link:usedOn>
				<link:usedOn>link:calculationLink</link:usedOn>
			</link:roleType>
			<link:roleType roleURI="http://www.cassinfo.com/role/SummaryOfSignificantAccountingPolicies" id="SummaryOfSignificantAccountingPolicies">
				<link:definition>008 - Disclosure - Summary of Significant Accounting Policies</link:definition>
				<link:usedOn>link:presentationLink</link:usedOn>
				<link:usedOn>link:definitionLink</link:usedOn>
				<link:usedOn>link:calculationLink</link:usedOn>
			</link:roleType>
			<link:roleType roleURI="http://www.cassinfo.com/role/CapitalRequirementsAndRegulatoryRestrictions" id="CapitalRequirementsAndRegulatoryRestrictions">
				<link:definition>009 - Disclosure - Capital Requirements and Regulatory Restrictions</link:definition>
				<link:usedOn>link:presentationLink</link:usedOn>
				<link:usedOn>link:definitionLink</link:usedOn>
				<link:usedOn>link:calculationLink</link:usedOn>
			</link:roleType>
			<link:roleType roleURI="http://www.cassinfo.com/role/InvestmentInSecurities" id="InvestmentInSecurities">
				<link:definition>010 - Disclosure - Investment in Securities</link:definition>
				<link:usedOn>link:presentationLink</link:usedOn>
				<link:usedOn>link:definitionLink</link:usedOn>
				<link:usedOn>link:calculationLink</link:usedOn>
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			<link:roleType roleURI="http://www.cassinfo.com/role/LoansByType" id="LoansByType">
				<link:definition>011 - Disclosure - Loans by Type</link:definition>
				<link:usedOn>link:presentationLink</link:usedOn>
				<link:usedOn>link:definitionLink</link:usedOn>
				<link:usedOn>link:calculationLink</link:usedOn>
			</link:roleType>
			<link:roleType roleURI="http://www.cassinfo.com/role/PremisesAndEquipment" id="PremisesAndEquipment">
				<link:definition>012 - Disclosure - Premises and Equipment</link:definition>
				<link:usedOn>link:presentationLink</link:usedOn>
				<link:usedOn>link:definitionLink</link:usedOn>
				<link:usedOn>link:calculationLink</link:usedOn>
			</link:roleType>
			<link:roleType roleURI="http://www.cassinfo.com/role/IntangibleAssets" id="IntangibleAssets">
				<link:definition>013 - Disclosure - Intangible Assets</link:definition>
				<link:usedOn>link:presentationLink</link:usedOn>
				<link:usedOn>link:definitionLink</link:usedOn>
				<link:usedOn>link:calculationLink</link:usedOn>
			</link:roleType>
			<link:roleType roleURI="http://www.cassinfo.com/role/InterestBearingDeposits" id="InterestBearingDeposits">
				<link:definition>014 - Disclosure - Interest-Bearing Deposits</link:definition>
				<link:usedOn>link:presentationLink</link:usedOn>
				<link:usedOn>link:definitionLink</link:usedOn>
				<link:usedOn>link:calculationLink</link:usedOn>
			</link:roleType>
			<link:roleType roleURI="http://www.cassinfo.com/role/SubordinatedConvertibleDebenturesAndUnusedAvailableLinesOfCredit" id="SubordinatedConvertibleDebenturesAndUnusedAvailableLinesOfCredit">
				<link:definition>015 - Disclosure - Subordinated Convertible Debentures and Unused Available Lines of Credit</link:definition>
				<link:usedOn>link:presentationLink</link:usedOn>
				<link:usedOn>link:definitionLink</link:usedOn>
				<link:usedOn>link:calculationLink</link:usedOn>
			</link:roleType>
			<link:roleType roleURI="http://www.cassinfo.com/role/EarningsPerShare" id="EarningsPerShare">
				<link:definition>016 - Disclosure - Earnings Per Share</link:definition>
				<link:usedOn>link:presentationLink</link:usedOn>
				<link:usedOn>link:definitionLink</link:usedOn>
				<link:usedOn>link:calculationLink</link:usedOn>
			</link:roleType>
			<link:roleType roleURI="http://www.cassinfo.com/role/DefinedPensionPlans" id="DefinedPensionPlans">
				<link:definition>017 - Disclosure - Defined Pension Plans</link:definition>
				<link:usedOn>link:presentationLink</link:usedOn>
				<link:usedOn>link:definitionLink</link:usedOn>
				<link:usedOn>link:calculationLink</link:usedOn>
			</link:roleType>
			<link:roleType roleURI="http://www.cassinfo.com/role/Stock-basedCompensation" id="Stock-basedCompensation">
				<link:definition>018 - Disclosure - Stock-Based Compensation</link:definition>
				<link:usedOn>link:presentationLink</link:usedOn>
				<link:usedOn>link:definitionLink</link:usedOn>
				<link:usedOn>link:calculationLink</link:usedOn>
			</link:roleType>
			<link:roleType roleURI="http://www.cassinfo.com/role/OtherOperatingExpense" id="OtherOperatingExpense">
				<link:definition>019 - Disclosure - Other Operating Expense</link:definition>
				<link:usedOn>link:presentationLink</link:usedOn>
				<link:usedOn>link:definitionLink</link:usedOn>
				<link:usedOn>link:calculationLink</link:usedOn>
			</link:roleType>
			<link:roleType roleURI="http://www.cassinfo.com/role/IncomeTaxes" id="IncomeTaxes">
				<link:definition>020 - Disclosure - Income Taxes</link:definition>
				<link:usedOn>link:presentationLink</link:usedOn>
				<link:usedOn>link:definitionLink</link:usedOn>
				<link:usedOn>link:calculationLink</link:usedOn>
			</link:roleType>
			<link:roleType roleURI="http://www.cassinfo.com/role/CommitmentsAndContingencies" id="CommitmentsAndContingencies">
				<link:definition>021 - Disclosure - Commitments and Contingencies</link:definition>
				<link:usedOn>link:presentationLink</link:usedOn>
				<link:usedOn>link:definitionLink</link:usedOn>
				<link:usedOn>link:calculationLink</link:usedOn>
			</link:roleType>
			<link:roleType roleURI="http://www.cassinfo.com/role/FairValueOfFinancialInstruments" id="FairValueOfFinancialInstruments">
				<link:definition>022 - Disclosure - Fair Value of Financial Instruments</link:definition>
				<link:usedOn>link:presentationLink</link:usedOn>
				<link:usedOn>link:definitionLink</link:usedOn>
				<link:usedOn>link:calculationLink</link:usedOn>
			</link:roleType>
			<link:roleType roleURI="http://www.cassinfo.com/role/IndustrySegmentInformation" id="IndustrySegmentInformation">
				<link:definition>023 - Disclosure - Industry Segment Information</link:definition>
				<link:usedOn>link:presentationLink</link:usedOn>
				<link:usedOn>link:definitionLink</link:usedOn>
				<link:usedOn>link:calculationLink</link:usedOn>
			</link:roleType>
			<link:roleType roleURI="http://www.cassinfo.com/role/SubsequentEvents" id="SubsequentEvents">
				<link:definition>024 - Disclosure - Subsequent Events</link:definition>
				<link:usedOn>link:presentationLink</link:usedOn>
				<link:usedOn>link:definitionLink</link:usedOn>
				<link:usedOn>link:calculationLink</link:usedOn>
			</link:roleType>
			<link:roleType roleURI="http://www.cassinfo.com/role/CondensedFinancialInformationOfParentCompany" id="CondensedFinancialInformationOfParentCompany">
				<link:definition>025 - Disclosure - Condensed Financial Information of Parent Company</link:definition>
				<link:usedOn>link:presentationLink</link:usedOn>
				<link:usedOn>link:definitionLink</link:usedOn>
				<link:usedOn>link:calculationLink</link:usedOn>
			</link:roleType>
			<link:roleType roleURI="http://www.cassinfo.com/role/SupplementaryFinancialInformation" id="SupplementaryFinancialInformation">
				<link:definition>026 - Disclosure - SUPPLEMENTARY FINANCIAL INFORMATION</link:definition>
				<link:usedOn>link:presentationLink</link:usedOn>
				<link:usedOn>link:definitionLink</link:usedOn>
				<link:usedOn>link:calculationLink</link:usedOn>
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			<link:linkbaseRef xlink:type="simple" xlink:href="cass-20111231_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase"/>
			<link:linkbaseRef xlink:type="simple" xlink:href="cass-20111231_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase"/>
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