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Note F - Common Stock and Warrants (Tables)
 6 Months Ended
Jun. 30, 2016
Notes Tables  
Schedule of Authorized Shares of Common Stock Reserved for Future Issuance [Table Text Block]
   
June 30
,
2016
    
December 31,
2015
  
Conversion of Deerfield Convertible Notes
     2,088,931       1,991,219  
Conversion
of 2021 Notes
     5,040,914       —  
Outstanding awards under equity incentive plans
     2,238,153       1,397,511  
Outstanding common stock warrants
     2,087,477       2,325,383  
Possible future issuances under equity incentive plans
     1,130,111       1,410,848  
Total common
shares reserved for future issuance
     12,585,586       7,124,961  
Schedule of Common Stock Outstanding Roll Forward [Table Text Block]
   
Shares of
Common Stock
  
Balance at December 31, 2015
     14,490,954  
Common stock warrants exercised     141,095  
Common stock options exercised
     14,933  
Balance at
June 30, 2016
     14,646,982