<SEC-DOCUMENT>0001437749-19-003803.txt : 20190301
<SEC-HEADER>0001437749-19-003803.hdr.sgml : 20190301
<ACCEPTANCE-DATETIME>20190301172820
ACCESSION NUMBER:		0001437749-19-003803
CONFORMED SUBMISSION TYPE:	S-8
PUBLIC DOCUMENT COUNT:		4
FILED AS OF DATE:		20190301
DATE AS OF CHANGE:		20190301
EFFECTIVENESS DATE:		20190301

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			KEMPHARM, INC
		CENTRAL INDEX KEY:			0001434647
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				205894398
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-8
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-230041
		FILM NUMBER:		19650832

	BUSINESS ADDRESS:	
		STREET 1:		1180 CELEBRATION BOULEVARD, SUITE 103
		CITY:			CELEBRATION
		STATE:			FL
		ZIP:			34747
		BUSINESS PHONE:		(321) 939-3416

	MAIL ADDRESS:	
		STREET 1:		1180 CELEBRATION BOULEVARD, SUITE 103
		CITY:			CELEBRATION
		STATE:			FL
		ZIP:			34747

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	KEMPHARM INC
		DATE OF NAME CHANGE:	20080507
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-8
<SEQUENCE>1
<FILENAME>kmph20190220_s8.htm
<DESCRIPTION>FORM S-8
<TEXT>
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<p style="margin: 0pt; text-align: center; color: rgb(0, 0, 0); text-indent: 0pt; font-family: Times New Roman; font-size: 10pt; background-color: rgb(255, 255, 255);"><font style="font-family: Times New Roman, Times, serif; font-size: 10pt;"><b>As filed with the Securities and Exchange Commission on&nbsp;March</b><b> 1</b><b>, 2019</b> </font></p>

<p style="margin: 0pt; text-align: right; font-family: Times New Roman, Times, serif; font-size: 10pt;"><b>Registration No. 333- </b></p>

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<p style="margin: 0pt 54pt 0pt 51.1pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 18pt;"><b>UNITED STATES</b></p>

<p style="margin: 0pt 54pt 0pt 51.15pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 18pt;"><b>SECURITIES AND EXCHANGE COMMISSION</b></p>

<p style="margin: 0pt 54pt 0pt 51.15pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>WASHINGTON, D.C. 20549</b></p>

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<p style="margin: 0pt 54pt 0pt 51.1pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 18pt;"><b>FORM S-8</b></p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 18pt;"><b>REGISTRATION STATEMENT </b></p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><i>UNDER&nbsp; </i></p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><i>THE SECURITIES ACT OF 1933</i></p>

<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;">&nbsp;</p>

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<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: center; color: rgb(0, 0, 0); text-indent: 0pt; font-family: Times New Roman; font-size: 24pt; background-color: rgb(255, 255, 255);"><b>KemPharm</b><b>, Inc.</b></p>

<p style="margin: 0pt 54pt 0pt 51.15pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>(Exact Name of Registrant as Specified in Its Charter)</b></p>

<p style="font-family: Times New Roman, Times, serif; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;">&nbsp;</p>

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			<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>Delaware</b></p>
			</td>
			<td style="width: 18%; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td style="width: 37.7%; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt; vertical-align: top;">
			<p style="margin: 0pt 1.8pt 0pt 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>20</b><b>-</b><b>5894398</b></p>
			</td>
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			<td style="width: 44.3%; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>(State or Other Jurisdiction of Incorporation or Organization)</b></p>
			</td>
			<td style="width: 18%; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td style="width: 37.7%; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt; vertical-align: top;">
			<p style="margin: 0pt 1.8pt 0pt 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>(I.R.S. Employer Identification No.)</b></p>
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<p style="margin: 0pt 54pt 0pt 0pt; text-align: justify; font-family: Times New Roman, Times, serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>1180&nbsp;Celebration Boulevard, Suite </b><b>103</b></p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>Celebration,&nbsp;FL 34747</b></p>

<hr style="margin: 3pt auto; border: currentColor; border-image: none; width: 25%; height: 1px; text-align: center; color: rgb(0, 0, 0); background-color: rgb(0, 0, 0);">
<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>(Address of Principal Executive Offices) (Zip Code)</b></p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>&nbsp;</b></p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>2014 Equity Incentive Plan</b></p>

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<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>(Full Title of the Plan)</b></p>

<p style="font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>R. LaDuane Clifton, CPA</b></p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>Chief Financial Officer, Secretary and Treasurer</b></p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>KemPharm</b><b>, Inc.</b></p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>1180&nbsp;Celebration Boulevard, Suite 103</b></p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>Celebration,&nbsp;FL 34747</b></p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>(</b><b>321</b><b>) 939</b><b>-3416</b></p>

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<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>(Name and Address of Agent for Service) (Telephone Number, Including Area Code, of Agent for Service)</b></p>

<p style="font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b><i>Copies to:</i></b></p>

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			<td colspan="2" style="width: 48.4%; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt; vertical-align: middle;">
			<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>Brent B. Siler</b></p>

			<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>Matthew P. Dubofsky</b></p>

			<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>Cooley LLP</b></p>

			<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>380 Interlocken Crescent, Suite 900</b></p>

			<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>Broomfield, CO 80021</b></p>

			<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><b>(720) 566-4000</b></p>
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<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;"><i>&nbsp;</i></p>

<p style="margin: 0pt; text-align: justify; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of &ldquo;large accelerated filer,&rdquo; &ldquo;accelerated filer&rdquo; and &ldquo;smaller reporting company&rdquo; in Rule 12b-2 of the Exchange Act.</p>

<p style="margin: 0pt; text-align: justify; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: justify; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;">Large accelerated filer &#9744;&nbsp;&nbsp;&nbsp;&nbsp; Accelerated filer &#9744;&nbsp;&nbsp;&nbsp;&nbsp; Non-accelerated filer &#9744; (Do not check if a smaller reporting company)&nbsp;&nbsp;&nbsp;&nbsp; Smaller reporting company&nbsp;&#9746;&nbsp;&nbsp;&nbsp;&nbsp;</p>

<p style="margin: 0pt; text-align: justify; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: justify; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (&sect;<font style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">&nbsp;230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (&sect; 240.12b-2 of this chapter).</font></p>

<p style="margin: 0pt; text-align: justify; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: justify; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;">Emerging growth company &#9746;</p>

<p style="font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: justify; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to<font style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">&nbsp;Section 13(a) of the Exchange Act.&nbsp;&nbsp;&#9746;</font></p>

<p style="margin: 0pt; text-align: justify; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">&nbsp;</p>

<div id="PGBK" style="width: 100%; margin-right: 0pt; margin-left: 0pt;">
<div id="PGNUM" style="width: 100%; text-align: center;">&nbsp;</div>

<hr style="border: currentColor; border-image: none; width: 100%; height: 2px; color: rgb(0, 0, 0); page-break-after: always; background-color: rgb(0, 0, 0);">
<div id="PGHDR" style="width: 100%; text-align: left;">&nbsp;</div>
</div>

<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;"><b>CALCULATION OF REGISTRATION FEE</b></p>

<p style="font-family: Times New Roman; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;">&nbsp;</p>

<table border="0" cellpadding="0" cellspacing="0" id="TBL4" style="width: 100%; text-indent: 0px; font-family: Times New Roman, Times, serif; font-size: 10pt;">

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			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;"><b>Title of Securities to be Registered</b></p>
			</td>
			<td style="border: thin solid rgb(0, 0, 0); border-image: none; width: 17.1%; vertical-align: bottom;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;"><b>Amount to be </b></p>

			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;"><b>Registered (1)</b></p>
			</td>
			<td style="border: thin solid rgb(0, 0, 0); border-image: none; width: 16.5%; vertical-align: bottom;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;"><b>Proposed </b></p>

			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;"><b>Maximum Offering</b></p>

			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;"><b>Price Per Share (2)</b></p>
			</td>
			<td style="border: thin solid rgb(0, 0, 0); border-image: none; width: 20%; vertical-align: bottom;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;"><b>Proposed </b></p>

			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;"><b>Maximum Aggregate </b></p>

			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;"><b>Offering Price (2)</b></p>
			</td>
			<td style="border: thin solid rgb(0, 0, 0); border-image: none; width: 14.6%; vertical-align: bottom;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;"><b>Amount of</b></p>

			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;"><b>Registration Fee</b></p>
			</td>
		</tr>
		<tr>
			<td style="border: thin solid rgb(0, 0, 0); border-image: none; width: 36.6%; vertical-align: middle;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;">Common Stock, par value $0.0<font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">001 per share</font></p>
			</td>
			<td style="border: thin solid rgb(0, 0, 0); border-image: none; width: 17.1%; vertical-align: middle;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;"><font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">1,058,214&nbsp;shares</font></p>
			</td>
			<td style="border: thin solid rgb(0, 0, 0); border-image: none; width: 16.5%; vertical-align: middle;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;">$2.18</p>
			</td>
			<td style="border: thin solid rgb(0, 0, 0); border-image: none; width: 20%; vertical-align: middle;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;">$2,306,906.52</p>
			</td>
			<td style="border: thin solid rgb(0, 0, 0); border-image: none; width: 14.6%; vertical-align: middle;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;">$279.60</p>
			</td>
		</tr>

</table>

<p style="margin: 0pt; text-align: justify; font-family: Times New Roman; font-size: 10pt;">&nbsp;</p>

<table border="0" cellpadding="0" cellspacing="0" id="TBL5" style="margin: 0pt; width: 100%; text-indent: 0px; font-size: 10pt;">

		<tr>
			<td style="width: 4%; vertical-align: top;">
			<p style="margin: 0pt; text-align: justify; font-family: Times New Roman; font-size: 10pt;">(1)</p>
			</td>
			<td style="width: 96%; vertical-align: top;">
			<p style="margin: 0pt; text-align: justify; font-family: Times New Roman; font-size: 10pt;">Pursuant to Rule 416(a) of the Securities Act of 1933, as amended (the &ldquo;<font style="font-family: Times New Roman, Times, serif; font-size: 10pt;"><b><i>Securities Act</i></b>&rdquo;), this Registration Statement shall also cover any additional shares of the Registrant&rsquo;s common stock, par value $0.0001 (the &ldquo;<b><i>Common Stock</i></b>&rdquo;) that become issuable under the 2014 Equity Incentive Plan (the &ldquo;<b><i>2014 </i></b><b><i>Plan</i></b>&rdquo;) by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without receipt of consideration that increases the number of the Registrant&rsquo;s outstanding shares of Common Stock.</font></p>
			</td>
		</tr>
		<tr>
			<td style="width: 4%; vertical-align: top;">
			<p style="margin: 0pt; text-align: justify; font-family: Times New Roman; font-size: 10pt;">(2)</p>
			</td>
			<td style="width: 96%; vertical-align: top;">
			<p style="margin: 0pt; text-align: justify; font-family: Times New Roman; font-size: 10pt;">Estimated solely for the purpose of calculating the amount of the registration fee pursuant to Rule 457(h) and Rule 457(c) promulg<font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">ated under the Securities Act. The offering price per share and the aggregate offering price are based upon the average high and low prices of the Registrant&rsquo;s Common Stock as reported on the N<font style="text-transform: lowercase;">ASDAQ</font> Global Market on&nbsp;February 25, 2019. The chart below details the calculations of the registration fee:</font></p>
			</td>
		</tr>

</table>

<p style="margin: 0pt; text-align: justify; font-family: Times New Roman; font-size: 10pt;">&nbsp;</p>

<table border="0" cellpadding="0" cellspacing="0" id="TBL6" style="width: 100%; text-indent: 0px; font-family: Times New Roman, Times, serif; font-size: 10pt;">

		<tr>
			<td style="border: thin solid rgb(0, 0, 0); border-image: none; width: 48.8%; vertical-align: bottom;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;"><b>Securities </b></p>
			</td>
			<td style="border: thin solid rgb(0, 0, 0); border-image: none; width: 16.4%; vertical-align: bottom;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;"><b>Number of </b></p>

			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;"><b>Shares</b></p>
			</td>
			<td style="border: thin solid rgb(0, 0, 0); border-image: none; width: 18.8%; vertical-align: bottom;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;"><b>Offering Price </b></p>

			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;"><b>Per Share (2)</b></p>
			</td>
			<td style="border: thin solid rgb(0, 0, 0); border-image: none; width: 17.2%; vertical-align: bottom;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;"><b>Aggregate </b></p>

			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;"><b>Offering Price</b></p>
			</td>
		</tr>
		<tr>
			<td style="border: thin solid rgb(0, 0, 0); border-image: none; width: 48.8%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;">Additional shares reserved for future grant under the <font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">2014 Plan</font></p>
			</td>
			<td style="border: thin solid rgb(0, 0, 0); border-image: none; width: 16.4%; text-align: center; vertical-align: top;">1,058,214</td>
			<td style="border: thin solid rgb(0, 0, 0); border-image: none; width: 18.8%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;">$2.18<font style="font-family: Times New Roman, Times, serif; font-size: 10pt;"> (2)</font></p>
			</td>
			<td style="border: thin solid rgb(0, 0, 0); border-image: none; width: 17.2%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;">$2,306,906.52</p>
			</td>
		</tr>
		<tr>
			<td style="border: thin solid rgb(0, 0, 0); border-image: none; width: 48.8%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;">Proposed Maximum Aggregate Offering Price</p>
			</td>
			<td style="border: thin solid rgb(0, 0, 0); border-image: none; width: 16.4%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td style="border: thin solid rgb(0, 0, 0); border-image: none; width: 18.8%; vertical-align: top;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">&nbsp;</p>
			</td>
			<td style="border: thin solid rgb(0, 0, 0); border-image: none; width: 17.2%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;">$2,306,906.52</p>
			</td>
		</tr>
		<tr>
			<td style="border: thin solid rgb(0, 0, 0); border-image: none; width: 48.8%; vertical-align: middle;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;"><b>Registration Fee</b></p>
			</td>
			<td style="border: thin solid rgb(0, 0, 0); border-image: none; width: 16.4%; font-family: Times New Roman; font-size: 10pt; vertical-align: middle;">&nbsp;</td>
			<td style="border: thin solid rgb(0, 0, 0); border-image: none; width: 18.8%; font-family: Times New Roman; font-size: 10pt; vertical-align: middle;">&nbsp;</td>
			<td style="border: thin solid rgb(0, 0, 0); border-image: none; width: 17.2%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;">$279.60</p>
			</td>
		</tr>

</table>

<p style="margin: 0pt 36pt; text-align: center; text-transform: uppercase; text-indent: -36pt; font-family: Times New Roman, Times, serif; font-size: 10pt;">&nbsp;</p>

<div id="PGBK" style="width: 100%; margin-right: 0pt; margin-left: 0pt;">
<div id="PGNUM" style="width: 100%; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;">2</div>

<hr style="border: currentColor; border-image: none; width: 100%; height: 2px; color: rgb(0, 0, 0); page-break-after: always; background-color: rgb(0, 0, 0);">
<div id="PGHDR" style="width: 100%; text-align: left;">&nbsp;</div>
</div>

<p style="margin: 0pt 36pt; text-align: center; text-transform: uppercase; text-indent: -36pt; font-family: Times New Roman, Times, serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: center; text-transform: uppercase; font-family: Times New Roman, Times, serif; font-size: 10pt;"><b>Explanatory Note</b></p>

<p style="font-family: Times New Roman, Times, serif; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: justify; font-family: Times New Roman, Times, serif; font-size: 10pt;">This Registration Statement on Form S-8 is being filed for the purpose of registering an <font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">additional&nbsp;1,058,214 shares of the Registrant&rsquo;s Common Stock to be issued pursuant to the Registrant&rsquo;s 2014 Plan.</font></p>

<p style="margin: 0pt; text-align: justify; text-indent: 36pt; font-family: Times New Roman, Times, serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;"><b>INCORPORATION BY REFERENCE OF CONTENTS OF REGISTRATION </b></p>

<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;"><b>STATEMENT ON FORM S-8 </b></p>

<p style="font-family: Times New Roman, Times, serif; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: justify; font-family: Times New Roman, Times, serif; font-size: 10pt;">The R<font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">egistrant is hereby registering an additional&nbsp;1,058,214 shares of the Registrant&rsquo;s Common Stock to be issued pursuant to the Registrant&rsquo;s 2014 Plan. The contents of the Registration Statement on Form&nbsp;S-8 (File No. 333-203703), as filed with the Securities and Exchange Commission (the &ldquo;<b><i>Commission</i></b>&rdquo;) on April 29, 2015, are incorporated herein by reference and made a part of this Registration Statement.</font></p>

<p style="margin: 0pt; text-align: justify; font-family: Times New Roman, Times, serif; font-size: 10pt;">&nbsp;</p>

<div id="PGBK" style="width: 100%; margin-right: 0pt; margin-left: 0pt;">
<div id="PGNUM" style="width: 100%; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;">3</div>

<hr style="border: currentColor; border-image: none; width: 100%; height: 2px; color: rgb(0, 0, 0); page-break-after: always; background-color: rgb(0, 0, 0);">
<div id="PGHDR" style="width: 100%; text-align: left;">&nbsp;</div>
</div>

<p style="margin: 0pt; text-align: left; font-family: Times New Roman, Times, serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: left; font-family: Times New Roman, Times, serif; font-size: 10pt;"><b>ITEM</b><font style="font-family: Times New Roman, Times, serif; font-size: 10pt;"><b>&nbsp;8.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;EXHIBITS</b></font></p>

<p style="font-family: Times New Roman, Times, serif; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;">&nbsp;</p>

<table border="0" cellpadding="0" cellspacing="0" id="TBL7" style="margin: 0pt; width: 100%; text-indent: 0px; font-size: 10pt;">

		<tr>
			<td style="width: 10.6%; vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: solid;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;"><b>Exhibit </b></p>

			<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;"><b>Number</b></p>
			</td>
			<td style="width: 90.5%; vertical-align: bottom; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: solid;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;"><b>Description</b></p>
			</td>
		</tr>
		<tr>
			<td style="width: 10.6%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;">4<font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">.1<sup>(</sup><sup>1</sup><sup>)</sup></font></p>
			</td>
			<td style="width: 90.5%; vertical-align: top;">
			<p style="margin: 0pt; text-align: justify; font-family: Times New Roman, Times, serif; font-size: 10pt;"><a href="http://www.sec.gov/Archives/edgar/data/1434647/000119312515140072/d911803dex31.htm" style="-sec-extract: exhibit;">Amended and Restated Certificate of Incorporation<font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">, as currently in effect.</font></a></p>
			</td>
		</tr>
		<tr>
			<td style="width: 10.6%; text-align: center; vertical-align: top;">4.2<sup>(2)</sup></td>
			<td style="width: 90.5%; vertical-align: top;"><a href="http://www.sec.gov/Archives/edgar/data/1434647/000119312518294252/d636304dex31.htm" style="-sec-extract: exhibit;">Certificate of Designation of Preferences, Rights and Limitations of Series A Convertible Preferred Stock</a></td>
		</tr>
		<tr>
			<td style="width: 10.6%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;">4<font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">.3<sup>(3</sup><sup>)</sup></font></p>
			</td>
			<td style="width: 90.5%; vertical-align: top;">
			<p style="margin: 0pt; text-align: justify; font-family: Times New Roman, Times, serif; font-size: 10pt;"><a href="http://www.sec.gov/Archives/edgar/data/1434647/000119312515140072/d911803dex32.htm" style="-sec-extract: exhibit;">Amended and Restated Bylaws<font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">, as currently in effect.</font></a></p>
			</td>
		</tr>
		<tr>
			<td style="width: 10.6%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;">4<font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">.4<sup>(4</sup><sup>)</sup></font></p>
			</td>
			<td style="width: 90.5%; vertical-align: top;">
			<p style="margin: 0pt; text-align: justify; font-family: Times New Roman, Times, serif; font-size: 10pt;"><a href="http://www.sec.gov/Archives/edgar/data/1434647/000119312515124387/d793437dex42.htm" style="-sec-extract: exhibit;">Specimen stock certificate evidencing shares of Common Stock.</a></p>
			</td>
		</tr>
		<tr>
			<td style="width: 10.6%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;">4.5<font style="font-family: Times New Roman, Times, serif; font-size: 10pt;"><sup>(5</sup><sup>)</sup></font></p>
			</td>
			<td style="width: 90.5%; vertical-align: top;">
			<p style="margin: 0pt; text-align: justify; font-family: Times New Roman, Times, serif; font-size: 10pt;"><a href="http://www.sec.gov/Archives/edgar/data/1434647/000119312515154390/d913215dex47.htm" style="-sec-extract: exhibit;">2014<font style="font-family: Times New Roman, Times, serif; font-size: 10pt;"> Equity Incentive Plan.</font></a></p>
			</td>
		</tr>
		<tr>
			<td style="width: 10.6%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;">4.6<font style="font-family: Times New Roman, Times, serif; font-size: 10pt;"><sup>(6</sup><sup>)</sup></font></p>
			</td>
			<td style="width: 90.5%; vertical-align: top;">
			<p style="margin: 0pt; text-align: justify; font-family: Times New Roman, Times, serif; font-size: 10pt;"><a href="http://www.sec.gov/Archives/edgar/data/1434647/000119312515087360/d793437dex1015.htm" style="-sec-extract: exhibit;">Form of Stock Option Grant Notice and Stock Option Agreement under 2014 Equity Incentive Plan.</a></p>
			</td>
		</tr>
		<tr>
			<td style="width: 10.6%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;">4.7<font style="font-family: Times New Roman, Times, serif; font-size: 10pt;"><sup>(7</sup><sup>)</sup></font></p>
			</td>
			<td style="width: 90.5%; vertical-align: top;">
			<p style="margin: 0pt; text-align: justify; font-family: Times New Roman, Times, serif; font-size: 10pt;"><a href="http://www.sec.gov/Archives/edgar/data/1434647/000119312515087360/d793437dex1016.htm" style="-sec-extract: exhibit;">Form of Restricted Stock Unit Grant Notice and Restricted Stock Unit Award Agreement under 2014 Equity Incentive Plan.</a></p>
			</td>
		</tr>
		<tr>
			<td style="width: 10.6%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;">5.1</p>
			</td>
			<td style="width: 90.5%; vertical-align: top;">
			<p style="margin: 0pt; text-align: justify; font-family: Times New Roman, Times, serif; font-size: 10pt;"><a id="Exhibit 5.1" name="Exhibit 5.1"></a><a href="ex_135368.htm" style="-sec-extract: exhibit;">Opinion of Cooley LLP.</a></p>
			</td>
		</tr>
		<tr>
			<td style="width: 10.6%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;">23.1</p>
			</td>
			<td style="width: 90.5%; vertical-align: top;">
			<p style="margin: 0pt; text-align: justify; font-family: Times New Roman, Times, serif; font-size: 10pt;"><a href="ex_135369.htm" style="-sec-extract: exhibit;">Consent of&nbsp;RSM US<font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">&nbsp;LLP, independent registered public accounting firm.</font></a></p>
			</td>
		</tr>
		<tr>
			<td style="width: 10.6%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;">23.3</p>
			</td>
			<td style="width: 90.5%; vertical-align: top;">
			<p style="margin: 0pt; text-align: justify; font-family: Times New Roman, Times, serif; font-size: 10pt;"><a href="#Exhibit" style="-sec-extract: exhibit;">Consent of Cooley LLP (included in Exhibit 5.1).</a></p>
			</td>
		</tr>
		<tr>
			<td style="width: 10.6%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;">24.1</p>
			</td>
			<td style="width: 90.5%; vertical-align: top;">
			<p style="margin: 0pt; text-align: justify; font-family: Times New Roman, Times, serif; font-size: 10pt;"><a href="#Power" style="-sec-extract: exhibit;">Power of Attorney (included on the signature page of this Form S-8).</a></p>
			</td>
		</tr>

</table>

<p style="margin: 0pt; text-align: left; font-family: Times New Roman, Times, serif; font-size: 10pt;">&nbsp;</p>

<table border="0" cellpadding="0" cellspacing="0" id="TBL8" style="width: 100%; text-indent: 0px; font-family: Times New Roman, Times, serif; font-size: 10pt;">

		<tr>
			<td style="width: 4%; vertical-align: top; border-top-color: rgb(0, 0, 0); border-top-width: thin; border-top-style: solid;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman, Times, serif; font-size: 10pt;">(1)</p>
			</td>
			<td style="width: 96%; vertical-align: top; border-top-color: rgb(0, 0, 0); border-top-width: thin; border-top-style: solid;">
			<p style="margin: 0pt; text-align: justify; font-family: Times New Roman, Times, serif; font-size: 10pt;">Previously filed as Exhibit 3.1 to the Registrant<font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">&rsquo;s Current Report on Form 8-K (File No.&nbsp;001-36913), filed with the Commission on April&nbsp;21, 2015, and incorporated by reference herein. </font></p>
			</td>
		</tr>

</table>

<table border="0" cellpadding="0" cellspacing="0" id="TBL9" style="width: 100%; text-indent: 0px; font-family: Times New Roman, Times, serif; font-size: 10pt;">

		<tr>
			<td style="width: 4%; vertical-align: top;">(2)</td>
			<td style="width: 96%; vertical-align: top;">Previously filed as Exhibit 3.1 to the Registrant&rsquo;s Current Report on Form 8-K (File No.&nbsp;001-36913), filed with the Commission on&nbsp;October&nbsp;5, 2018, and incorporated by reference herein.</td>
		</tr>
		<tr>
			<td style="width: 4%; vertical-align: top;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman, Times, serif; font-size: 10pt;">(3)</p>
			</td>
			<td style="width: 96%; vertical-align: top;">
			<p style="margin: 0pt; text-align: justify; font-family: Times New Roman, Times, serif; font-size: 10pt;">Previously filed as Exhibit 3.2 to the Registrant<font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">&rsquo;s Current Report on Form 8-K (File No.&nbsp;001-36913), filed with the Commission on April 21, 2015, and incorporated by reference herein. </font></p>
			</td>
		</tr>

</table>

<table border="0" cellpadding="0" cellspacing="0" id="TBL10" style="width: 100%; text-indent: 0px; font-family: Times New Roman, Times, serif; font-size: 10pt;">

		<tr>
			<td style="width: 4%; vertical-align: top;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman, Times, serif; font-size: 10pt;">(4)</p>
			</td>
			<td style="width: 96%; vertical-align: top;">
			<p style="margin: 0pt; text-align: justify; font-family: Times New Roman, Times, serif; font-size: 10pt;">Previously filed as Exhibit 4.2 to Amendment No.<font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">&nbsp;2 to the Registrant&rsquo;s Registration Statement on Form S-1 (File No.&nbsp;333-202660), filed with the Commission on April&nbsp;9, 2015, and incorporated by reference herein. </font></p>
			</td>
		</tr>

</table>

<table border="0" cellpadding="0" cellspacing="0" id="TBL11" style="width: 100%; text-indent: 0px; font-family: Times New Roman, Times, serif; font-size: 10pt;">

		<tr>
			<td style="width: 4%; vertical-align: top;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman, Times, serif; font-size: 10pt;">(5<font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">)</font></p>
			</td>
			<td style="width: 96%; vertical-align: top;">
			<p style="margin: 0pt; text-align: justify; font-family: Times New Roman, Times, serif; font-size: 10pt;">Previously filed as Exhibit <font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">4.7 to the Registrant&rsquo;s Registration Statement on Form S-8 (File No.&nbsp;333-203703), filed with the Commission on April 29, 2015, and incorporated by reference herein. </font></p>
			</td>
		</tr>

</table>

<table border="0" cellpadding="0" cellspacing="0" id="TBL12" style="width: 100%; text-indent: 0px; font-family: Times New Roman, Times, serif; font-size: 10pt;">

		<tr>
			<td style="width: 4%; vertical-align: top;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman, Times, serif; font-size: 10pt;">(6<font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">)</font></p>
			</td>
			<td style="width: 96%; vertical-align: top;">
			<p style="margin: 0pt; text-align: justify; font-family: Times New Roman, Times, serif; font-size: 10pt;">Previously filed as Exhibit 10.15 to the Registrant<font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">&rsquo;s Registration Statement on Form S-1 (File No.&nbsp;333-202660), filed with the Commission on March&nbsp;11, 2015, and incorporated by reference herein. </font></p>
			</td>
		</tr>

</table>

<table border="0" cellpadding="0" cellspacing="0" id="TBL13" style="width: 100%; text-indent: 0px; font-family: Times New Roman, Times, serif; font-size: 10pt;">

		<tr>
			<td style="width: 4%; vertical-align: top;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman, Times, serif; font-size: 10pt;">(7<font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">)</font></p>
			</td>
			<td style="width: 96%; vertical-align: top;">
			<p style="margin: 0pt; text-align: justify; font-family: Times New Roman, Times, serif; font-size: 10pt;">Previously filed as Exhibit 10.16 to the Registrant<font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">&rsquo;s Registration Statement on Form S-1 (File No.&nbsp;333-202660), filed with the Commission on March&nbsp;11, 2015, and incorporated by reference herein.</font></p>
			</td>
		</tr>

</table>

<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;">&nbsp;</p>

<div id="PGBK" style="width: 100%; margin-right: 0pt; margin-left: 0pt;">
<div id="PGNUM" style="width: 100%; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;">4</div>

<hr style="border: currentColor; border-image: none; width: 100%; height: 2px; color: rgb(0, 0, 0); page-break-after: always; background-color: rgb(0, 0, 0);">
<div id="PGHDR" style="width: 100%; text-align: left;">&nbsp;</div>
</div>

<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;"><b>SIGNATURES</b></p>

<p style="font-family: Times New Roman; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: justify; font-family: Times New Roman; font-size: 10pt;">Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form<font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">&nbsp;S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Celebration, State of Florida, on this 1st day of March, 2019.</font></p>

<p style="font-family: Times New Roman; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;">&nbsp;</p>

<table border="0" cellpadding="0" cellspacing="0" style="margin: 0pt 0pt 0pt auto; width: 50%; font-family: Times New Roman; font-size: 10pt;">

		<tr>
			<td colspan="2" style="width: 5%;"><b>KemPharm, Inc.</b></td>
			<td style="width: 20%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="width: 5%;">&nbsp;</td>
			<td style="width: 75%;">&nbsp;</td>
			<td style="width: 20%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="width: 5%;">By:</td>
			<td style="width: 75%; border-bottom-color: rgb(0, 0, 0); border-bottom-width: thin; border-bottom-style: solid;">/s/ R. LaDuane Clifton</td>
			<td style="width: 20%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="width: 5%;">&nbsp;</td>
			<td style="width: 75%;">R. LaDuane Clifton, CPA</td>
			<td style="width: 20%;">&nbsp;</td>
		</tr>
		<tr>
			<td style="width: 5%;">&nbsp;</td>
			<td style="width: 75%;"><i>Chief Financial Officer, Secretary and Treasurer</i></td>
			<td style="width: 20%;">&nbsp;</td>
		</tr>

</table>

<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;">&nbsp;</p>

<div id="PGBK" style="width: 100%; margin-right: 0pt; margin-left: 0pt;">
<div id="PGNUM" style="width: 100%; text-align: center; font-family: &quot;Times New Roman&quot;, Times, Serif; font-size: 10pt;">5</div>

<hr style="border: currentColor; border-image: none; width: 100%; height: 2px; color: rgb(0, 0, 0); page-break-after: always; background-color: rgb(0, 0, 0);">
<div id="PGHDR" style="width: 100%; text-align: left;">&nbsp;</div>
</div>

<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;"><b><a id="Power of Attorney Title" name="Power of Attorney Title"></a>POWER OF ATTORNEY</b></p>

<p style="font-family: Times New Roman; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: justify; font-family: Times New Roman; font-size: 10pt;">KNOW ALL BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints <font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">Travis C. Mickle, Ph.D. and R. LaDuane Clifton, CPA&nbsp;and each or any one of them, his lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them, or their or his substitutes or substitute, may lawfully do or cause to be done by virtue hereof.</font></p>

<p style="font-family: Times New Roman; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: justify; font-family: Times New Roman; font-size: 10pt;">Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.</p>

<p style="font-family: Times New Roman; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;">&nbsp;</p>

<table border="0" cellpadding="0" cellspacing="0" id="TBL14" style="width: 100%; text-indent: 0px; font-family: Times New Roman, Times, serif; font-size: 10pt;">

		<tr>
			<td style="width: 32%; text-align: center; vertical-align: middle; border-bottom-color: rgb(0, 0, 0); border-bottom-width: thin; border-bottom-style: solid;"><b>Signature</b></td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; text-align: center; font-family: Times New Roman; font-size: 10pt; vertical-align: middle; border-bottom-color: rgb(0, 0, 0); border-bottom-width: thin; border-bottom-style: solid;"><b>Title</b></td>
			<td style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: middle;">&nbsp;</td>
			<td colspan="1" style="width: 32%; text-align: center; font-family: Times New Roman; font-size: 10pt; vertical-align: middle; border-bottom-color: rgb(0, 0, 0); border-bottom-width: thin; border-bottom-style: solid;"><b>Date</b></td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: middle; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: solid;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">&nbsp;</p>

			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">/s/ Travis C. Mickle</p>
			</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; font-family: Times New Roman; font-size: 10pt; vertical-align: middle;">&nbsp;</td>
			<td style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: middle;">&nbsp;</td>
			<td colspan="1" style="width: 32%; font-family: Times New Roman; font-size: 10pt; vertical-align: middle;">&nbsp;</td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: top; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: none;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">Travis C. Mickle, Ph.D.</p>
			</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;">President, Chief Executive Officer and</p>

			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;"><font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">Chairman of the Board of Directors&nbsp;</font></p>

			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;"><i>(Principal Executive Officer)</i></p>
			</td>
			<td style="width: 2%; vertical-align: top;">&nbsp;</td>
			<td colspan="1" style="width: 32%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;">March&nbsp;1<font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">, 2019</font></p>
			</td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: middle; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: solid;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">/s/ R. LaDuane Clifton</p>
			</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; font-family: Times New Roman; font-size: 10pt; vertical-align: middle;">&nbsp;</td>
			<td style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: middle;">&nbsp;</td>
			<td colspan="1" style="width: 32%; font-family: Times New Roman; font-size: 10pt; vertical-align: middle;">&nbsp;</td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: top; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: none;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">R. LaDuane Clifton, CPA</p>
			</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;">Chief Financial Officer, <font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">Secretary and Treasurer</font></p>

			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;"><i>(Principal </i><font style="font-family: Times New Roman, Times, serif; font-size: 10pt;"><i>Financial </i><i>Officer)</i></font></p>
			</td>
			<td style="width: 2%; vertical-align: top;">&nbsp;</td>
			<td colspan="1" style="width: 32%; text-align: center; vertical-align: top;">March<font style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">&nbsp;1, 2019</font></td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: middle; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: solid;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">/s/ Timothy J. Sangiovanni</p>
			</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; font-family: Times New Roman; font-size: 10pt; vertical-align: middle;">&nbsp;</td>
			<td style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: middle;">&nbsp;</td>
			<td colspan="1" style="width: 32%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
		</tr>
		<tr>
			<td style="padding: 0px; width: 32%; vertical-align: top;">Timothy J. Sangiovanni, CPA</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; text-align: center; vertical-align: middle;">
			<p style="margin: 0pt; font-family: Times New Roman, Times, serif; font-size: 10pt;">Vice President, Corporate Controller</p>

			<p style="margin: 0pt; font-family: Times New Roman, Times, serif; font-size: 10pt;"><i>(Principal Accounting Officer)</i></p>
			</td>
			<td style="width: 2%; vertical-align: middle;">&nbsp;</td>
			<td colspan="1" style="width: 32%; text-align: center; vertical-align: top;">March<font style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">&nbsp;1, 2019</font></td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: top; border-bottom-color: rgb(0, 0, 0); border-bottom-width: thin; border-bottom-style: solid;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">/s/ Danny L. Thompson</p>
			</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;">&nbsp;</p>
			</td>
			<td style="width: 2%; vertical-align: top;">&nbsp;</td>
			<td colspan="1" style="width: 32%; text-align: center; vertical-align: top;">&nbsp;</td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: top; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: none;">Danny L. Thompson</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; text-align: center; vertical-align: top;">Director</td>
			<td style="width: 2%; vertical-align: top;">&nbsp;</td>
			<td colspan="1" style="width: 32%; text-align: center; vertical-align: top;">March<font style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">&nbsp;1, 2019</font></td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: middle; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: solid;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">&nbsp;</p>

			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">/s/ Matthew R. Plooster</p>
			</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; font-family: Times New Roman; font-size: 10pt; vertical-align: middle;">&nbsp;</td>
			<td style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: middle;">&nbsp;</td>
			<td colspan="1" style="width: 32%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: top; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: none;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">Matthew R. Plooster</p>
			</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;">Director</p>
			</td>
			<td style="width: 2%; vertical-align: top;">&nbsp;</td>
			<td colspan="1" style="width: 32%; text-align: center; vertical-align: top;">March<font style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">&nbsp;1, 2019</font></td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: middle; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: solid;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">&nbsp;</p>

			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">/s/ Richard W. Pascoe</p>
			</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; font-family: Times New Roman; font-size: 10pt; vertical-align: middle;">&nbsp;</td>
			<td style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: middle;">&nbsp;</td>
			<td colspan="1" style="width: 32%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: top; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: none;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">Richard W. Pascoe</p>
			</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;">Director</p>
			</td>
			<td style="width: 2%; vertical-align: top;">&nbsp;</td>
			<td colspan="1" style="width: 32%; text-align: center; vertical-align: top;">March<font style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">&nbsp;1, 2019</font></td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: top; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: solid;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">&nbsp;</p>

			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">/s/ Joseph B. Saluri</p>
			</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="1" style="width: 32%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: top; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: none;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">Joseph B. Saluri</p>
			</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;">Director</p>
			</td>
			<td style="width: 2%; vertical-align: top;">&nbsp;</td>
			<td colspan="1" style="width: 32%; text-align: center; vertical-align: top;">March<font style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">&nbsp;1, 2019</font></td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: top; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: solid;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">&nbsp;</p>

			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">/s/ David S. Tierney</p>
			</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="1" style="width: 32%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
		</tr>
		<tr>
			<td style="width: 32%; vertical-align: top; border-bottom-color: rgb(0, 0, 0); border-bottom-width: 1px; border-bottom-style: none;">
			<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">David <font style="font-family: Times New Roman, Times, serif; font-size: 10pt;">S. Tierney</font></p>
			</td>
			<td colspan="2" style="width: 2%; font-family: Times New Roman; font-size: 10pt; vertical-align: top;">&nbsp;</td>
			<td colspan="2" style="width: 32%; vertical-align: top;">
			<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;">Director</p>
			</td>
			<td style="width: 2%; vertical-align: top;">&nbsp;</td>
			<td colspan="1" style="width: 32%; text-align: center; vertical-align: top;">March<font style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">&nbsp;1, 2019</font></td>
		</tr>

</table>

<p style="margin: 0pt; text-align: justify; font-family: Times New Roman, Times, serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: center; font-family: Times New Roman, Times, serif; font-size: 10pt;">6</p>
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<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>ex_135368.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
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	<title>ex_102870.htm</title>
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<p style="text-align: right; margin-top: 0px; margin-bottom: 0px;"><font style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;"><b>Exhibit 5.1</b></font></p>

<p style="text-align: left; margin-top: 0px; margin-bottom: 0px;"><font style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">&nbsp;</font><img src="a1.jpg"></p>

<p style="margin: 0pt; text-align: left; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: left; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">Brent B. Siler</p>

<p style="margin: 0pt; text-align: left; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;"><font style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">+1&nbsp;202&nbsp;728 7040</font></p>

<p style="margin: 0pt; text-align: left; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">bsiler@cooley.com</p>

<p style="margin: 0pt; text-align: left; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: left; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: left; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: left; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">March<font style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;"> 1, 2019</font></p>

<p style="margin: 0pt; text-align: justify; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: left; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">KemPharm, Inc.</p>

<p style="margin: 0pt; text-align: left; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;"><font style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">1180 Celebration Boulevard, Suite 103</font></p>

<p style="margin: 0pt; text-align: left; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">Celebration,&nbsp;Florida 34747</p>

<p style="margin: 0pt; text-align: left; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: left; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;"><b>Re:<font style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Registration on Form S-8</font></b></p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: left; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">Ladies and Gentlemen:</p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: justify; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; background-color: rgb(255, 255, 255);">We have acted as counsel to KemPharm, Inc., a Delaware corporation (the &ldquo;Company&rdquo;)<font style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">, in connection with the filing of a registration statement on Form&nbsp;S-8 (the &ldquo;Registration Statement&rdquo;) with the Securities and Exchange Commission covering the offering of up to&nbsp;1,058,214 shares of the Company&rsquo;s Common Stock, $0.0001 par value (the &ldquo;Shares&rdquo;), pursuant to the Company&rsquo;s 2014 Equity Incentive Plan (the &ldquo;2014 Plan&rdquo;).</font></p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: justify; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; background-color: rgb(255, 255, 255);">In connection with this opinion, we have examined and relied upon (a) the Registration Statement and related Prospectus included therein, (b) the Company<font style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">&rsquo;s Amended and Restated Certificate of Incorporation and Amended and Restated Bylaws, each as currently in effect, (c) the 2014 Plan and (d) such other records, documents, certificates, memoranda, and other instruments as we deem necessary or appropriate to enable us to render the opinion expressed below. We have assumed the genuineness and authenticity of all documents submitted to us as originals and the conformity to originals of all documents submitted to us as copies thereof, and we have assumed the due execution and delivery of all documents where due execution and delivery are prerequisite to the effectiveness thereof. As to certain factual matters, we have relied upon a certificate of an officer of the Company and have not sought independently to verify such matters.</font></p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: justify; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; background-color: rgb(255, 255, 255);">Our opinion is expressed only with respect to the General Corporation Law of the State of Delaware<font style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">. We express no opinion to the extent that any other laws are applicable to the subject matter hereof and express no opinion and provide no assurance as to compliance with any federal or state securities law, rule or regulation.</font></p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: justify; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; background-color: rgb(255, 255, 255);">On the basis of the foregoing, and in reliance thereon, we are of the opinion that the Shares, when sold and issued in accordance with the 2014 Plan, the Registration Statement and related Prospectus, will be validly issued, fully paid, and nonassessable (except as to shares issued pursuant to certain deferred payment arrangements, which will be fully paid and nonassessable when such deferred payments are made in full).</p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: justify; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; background-color: rgb(255, 255, 255);">We consent to the filing of this opinion as an exhibit to the Registration Statement.</p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: justify; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">Sincerely,</p>

<p style="margin: 0pt; text-align: justify; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: justify; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; font-variant: small-caps;">Cooley LLP</p>

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: justify; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: justify; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">By:<font style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;"><u> </u><u>/s/&nbsp;Brent B. Siler&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</u></font></p>

<p style="margin: 0pt; text-align: justify; text-indent: 22.5pt; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;"><font style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">Brent B. Siler&nbsp;</font></p>

<p style="margin: 0pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt 7.5pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt 7.5pt; text-align: center; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">Cooley LLP&nbsp;&nbsp;&nbsp;1299 Pennsylvania Avenue, NW, Suite 700&nbsp;&nbsp; Washington, DC&nbsp;&nbsp; 20004-2400</p>
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<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>3
<FILENAME>ex_135369.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
<html>
<head>
	<title>ex_102871.htm</title>
	<meta charset="utf-8"><meta name="format-detection" content="telephone=no"/>
</head>
<body style="font-family: Times New Roman, Times, serif; font-size: 10pt; margin-right: 10px; margin-left: 10px;">
<p style="margin: 0pt; text-align: right; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;"><b>Exhibit 23.1</b></p>

<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: center; font-family: Times New Roman; font-size: 10pt;"><b>CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM</b></p>

<p style="margin: 0pt; text-align: justify; font-family: Times New Roman; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: justify; font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">We consent to the incorporation by reference in this Registration Statement on Form S-8 of KemPharm, Inc. of our report dated March 1, 2019, relating to the financial statements of KemPharm, Inc., appearing in the Annual Report on Form 10-K of KemPharm, <font style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 10pt;">Inc. for the year ended December 31, 2018.</font></p>

<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">/s/&nbsp;RSM US&nbsp;LLP</p>

<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">&nbsp;</p>

<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">Orlando, Florida</p>

<p style="margin: 0pt; text-align: left; font-family: Times New Roman; font-size: 10pt;">March&nbsp;1, 2019</p>
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